Results 41 to 50 of about 247,988 (211)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Could Trivalent LAIV Protect Against Both Genetic Lineages of Influenza B Virus?

Vaccine Research, 2019
Introduction: The global co-circulation of two influenza B virus genetic lineages known as B/Yamagata and B/Victoria may lead to a mismatch between the circulating virus and the strain recommended for use in influenza vaccines.
Irina Kiseleva, Ekaterina Stepanova, Elena Krutikova, Svetlana Donina, Andrey Rekstin, Ekaterina Bazhenova, Maria Pisareva, Anastasia Katelnikova, Kirill Kryshen, Arman Muzhikyan, Elena Grigorieva, Larisa Rudenko   +11 more
doaj  

Influenza virus infection of influenza-like illness at a sentinel hospital in Baoshan District of Shanghai from the monitoring year of 2015 to 2023

Shanghai yufang yixue
ObjectiveTo investigate the influenza virus infection status of influenza-like illness (ILI) at a sentinel hospital in Baoshan District of Shanghai, to explore the seasonal patterns of influenza, so as to provide a scientific basis for influenza ...
HU Yongdi, DOU Wenxia, XIANG Lunhui, GAO Ya, LIU Xiaofeng, HE Fan   +5 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of EdAP, a 4′-Ethynyl-2′-Deoxyadenosine 5′-Monophosphate Analog, as a Potent Influenza a Inhibitor

Molecules, 2019
Influenza A viruses leading to infectious respiratory diseases cause seasonal epidemics and sometimes periodic global pandemics. Viral polymerase is an attractive target in inhibiting viral replication, and 4′-ethynyladenosine, which has been ...
Toshifumi Takeuchi, Nongluk Sriwilaijaroen, Ayako Sakuraba, Ei Hayashi, Shinji Kamisuki, Yasuo Suzuki, Hiroshi Ohrui, Fumio Sugawara   +7 more
doaj   +1 more source

Influenza B viruses in the population of province of Vojvodina during the 2012/2013 season: Differentiation of B/Yamagata and B/Victoria lineages by real-time RT-PCR, antigenic and phylogenetic characterization [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2015
Introduction. At present, two phylogenetically distinct influenza B virus lineages, B/Yamagata and B/ Victoria, co-circulate worldwide and can cause significant morbidity and mortality. Objective.
Radovanov Jelena, Milošević Vesna, Hrnjaković-Cvjetković Ivana, Ristić Mioljub, Đilas Milan, Nikolić Nataša, Patić Aleksandra, Kovačević Gordana, Jovanović-Galović Aleksandra, Petrović Tamaš, Mikić Sandra Stefan   +10 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Analysis of influenza surveillance in Dehong Prefecture， Yunnan Province from 2016 to 2020

Shanghai yufang yixue, 2022
ObjectiveTo perform the analysis of influenza surveillance in Dehong from 2016 to 2020 and determine the epidemic situation of influenza and prevalent virus strains， so as to provide evidence for local influenza prevention and control.MethodsThe ...
YANG Shanrui, GUAN Guoping, KANG Hongjun, YANG Kang, LUO Dingfu   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation

Molecules, 2020
Influenza virus infections represent a major public health issue by causing annual epidemics and occasional pandemics that affect thousands of people worldwide.
Laurita Boff, André Schreiber, Aline da Rocha Matos, Juliana Del Sarto, Linda Brunotte, Jennifer Munkert, Flaviano Melo Ottoni, Gabriela Silva Ramos, Wolfgang Kreis, Fernão Castro Braga, Ricardo José Alves, Rodrigo Maia de Pádua, Cláudia Maria Oliveira Simões, Stephan Ludwig   +13 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source