Results 121 to 130 of about 155,020 (314)

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

INFLUENZA VACCINE SHORTAGES COULD BE MITIGATED BY APPLYING REGULATORY HARMONIZATION

, 2013
Seasonal and pandemic influenza vaccine shortages continue to occur despite regulatory agency recommendations and manufacturers' awareness. To achieve the public health goal of protecting the human population against seasonal influenza, vaccines will ...
Moore, Devon
core   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Next-generation intranasal influenza vaccines: mechanisms, platforms, and translational progress

Frontiers in Immunology
Seasonal influenza vaccination remains the most effective strategy for reducing influenza burden and preventing severe disease. Despite decades of vaccine development, the seasonal influenza vaccine is administered intramuscularly and provides suboptimal
Laise Rodrigues Reis, Ted M. Ross, Ted M. Ross, Ted M. Ross, Ted M. Ross   +4 more
doaj   +1 more source

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Knowledge, attitudes, barriers and uptake rate of influenza virus vaccine among children from 6 months to 5 years of age in Jordan: a multicentric cross-sectional study

Italian Journal of Pediatrics
Background Vaccination against influenza is the major primary preventive measure to reduce the major health and economic burden of influenza infections.
Munir Abu-Helalah, Nadine N. Abdelhadi, Mohammad Al-Hanaktah, Amro Asfour, Mea’ad Harahsheh, Rand Abu Mahfouz, Shahed Altarawneh, Mary Almadani, Lekaa Al Mughrabi   +8 more
doaj   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Influenza Other Respi Viruses [PDF]

BackgroundLimitations of the current annual influenza vaccine have led to ongoing efforts to develop a \u201cuniversal\u201d influenza vaccine, i.e., one that targets a ubiquitous portion of the influenza virus so that the coverage of a single ...

core  

Mathematical modeling for estimating influenza vaccine efficacy: A case study of the Valencian Community, Spain.

Infectious Disease Modelling
Vaccine efficacy and its quantification is a crucial concept for the proper design of public health vaccination policies. In this work we proposed a mathematical model to estimate the efficacy of the influenza vaccine in a real-word scenario.
Carlos Andreu-Vilarroig, Rafael J. Villanueva, Gilberto González-Parra   +2 more
doaj   +1 more source

Health economic considerations for pharmacogenomic services in the United Kingdom: The Centre for Excellence in Regulatory Science and Innovation in Pharmacogenomics

British Journal of Clinical Pharmacology, EarlyView.
Dyfrig A. Hughes, Henry Fong, Grace Hampson, Catrin O. Plumpton, Chris Sampson   +4 more
wiley   +1 more source