Results 151 to 160 of about 1,044,515 (400)
Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells
Advanced Science, EarlyView.ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen +11 more
wiley +1 more source
PLoS ONE, 2014 BackgroundThere is limited data on the epidemiology of influenza and few published estimates of influenza vaccine effectiveness (VE) from Africa. In April 2009, a new influenza virus strain infecting humans was identified and rapidly spread globally.
Genevie M Ntshoe +11 more
doaj +1 more source
, 2009 Examines capacities and challenges in preparing for and responding to an H1N1 flu pandemic, including vaccine issues, confusion with seasonal flu, strain on medical systems, and erosion of public health infrastructure.
core
A proof-of-principle study to identify suitable vaccine seed candidates to combat introductions of Eurasian lineage H5 and H7 subtype avian influenza viruses [PDF]
, 2010 Maria Serena Beato +4 more
openalex +1 more source
Journal of Infectious Diseases, 2019 BACKGROUND Increased illness due to antigenically drifted A(H3N2) clade 3C.3a influenza viruses prompted concerns about vaccine effectiveness and vaccine strain selection. We used U.S.
B. Flannery +22 more
semanticscholar +1 more source
Advanced Science, EarlyView.We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang +10 more
wiley +1 more source
Development of Universal Influenza Vaccines Targeting Conserved Viral Proteins
Vaccines, 2019 Vaccination is still the most efficient way to prevent an infection with influenza viruses. Nevertheless, existing commercial vaccines face serious limitations such as availability during epidemic outbreaks and their efficacy. Existing seasonal influenza
Seyed Davoud Jazayeri, Chit Laa Poh
doaj +1 more source
Vaccine Epidemiology and Decision-Making: A Bryant Student Focus [PDF]
, 2018 The Centers for Disease Control and Prevention estimate that influenza has resulted in between 9.2 and 35.6 million illnesses and between 12,000 and 56,000 deaths annually since 2010 (1).
Coburn, Hannah
core +1 more source
MARPLE: A Proximity‐Triggered CRISPR‐Cas13 Platform for Ultrasensitive Antibody Detection
Advanced Science, EarlyView.MARPLE is a modular CRISPR‐Cas13 immunoassay that uses antibody‐induced proximity to trigger a toehold‐exchange reaction, releasing an RNA activator for Cas13. This one‐pot, isothermal architecture enables ultrasensitive (femtomolar) and highly specific detection of diverse antibodies, including therapeutic, pathogen‐specific, and cancer‐associated ...
Elena Spezzani +6 more
wiley +1 more source