Results 241 to 250 of about 261,869 (302)

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

open access: yesThe FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner   +13 more
wiley   +1 more source

Evaluating inclusiveness and diversity in health misinformation correction research: A scoping review

open access: yesHealth Information &Libraries Journal, EarlyView.
Abstract Background The inclusion of marginalized populations in health information research is crucial for ensuring equitable health outcomes and addressing systemic disparities. However, underrepresentation of these groups remains a significant issue, particularly in health misinformation correction research.
Romy RW, Junhan Chen, Yuan Wang
wiley   +1 more source

Adsorption of antigen to polymeric nanoparticles enhances cytotoxic T‐cell responses and anti‐tumor immunity by targeting conventional type 1 dendritic cells

open access: yesImmunology &Cell Biology, EarlyView.
Therapeutic cancer vaccines require CD8+ T‐cell activation for efficacy. This response can be enhanced by rationally designing polymeric nanoparticle adjuvants. The importance of antigen location for the adjuvanticity of polymeric nanoparticles has not been fully resolved.
Jorge Huete‐Carrasco   +6 more
wiley   +1 more source

Delivery of PLGA-Loaded Influenza Vaccine Microparticles Using Dissolving Microneedles Induces a Robust Immune Response. [PDF]

open access: yesPharmaceutics
Adediran E   +10 more
europepmc   +1 more source

CD4+ tissue‐resident memory T cells and their role in immunity

open access: yesImmunology &Cell Biology, EarlyView.
In this article, we review and discuss the role of CD4+ tissue‐resident memory T (TRM) cells and their role in immune protection in tissues, such as the lungs, by facilitating pathogen clearance through cytokine production and local immune interactions.
Margarida Kirkby, Marc Veldhoen
wiley   +1 more source

Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects

open access: yesImmunology, EarlyView.
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder   +4 more
wiley   +1 more source

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