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Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects

open access: yesImmunology, EarlyView.
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder   +4 more
wiley   +1 more source

Should We Advance Our Understanding of Immunoglobulin E in Viral Immunity?

open access: yesImmunology, EarlyView.
Immunoglobulin E has been extensively studied in allergies and parasitic diseases. Antigen‐specific IgE has been identified as part of the humoral response to viruses. This revision speculates on possible functionalities for IgE, such as neutralisation, cytotoxicity and immunopathology of viral diseases, and provide insights about gaps to fill in ...
Amanda Izeli Portilho   +3 more
wiley   +1 more source

Navigating Flexibility and Standardisation in Low‐Code/No‐Code Development

open access: yesInformation Systems Journal, EarlyView.
ABSTRACT Low‐code/no‐code (LCNC) platforms, such as ServiceNow and Microsoft Power Platform, enable employees without formal IT training to build applications and automate workflows, thus driving agility and reducing dependence on traditional IT teams.
Altus Viljoen   +6 more
wiley   +1 more source

Comparing Genome Sequencing Methods to Reconstruct the Spread of Piscine Myocarditis Virus in Ireland

open access: yesJournal of Fish Diseases, EarlyView.
ABSTRACT Piscine myocarditis virus (PMCV), a double‐stranded RNA virus, is the causative agent of cardiomyopathy syndrome (CMS) in Atlantic salmon Salmo salar, which was first reported in Ireland in 2012. PMCV continues to be a disease threat to Atlantic salmon aquaculture in Ireland, and as such, it is of growing importance to understand how the virus
Andrew J. Tighe   +2 more
wiley   +1 more source

Safety of quadrivalent recombinant influenza vaccine in pregnant persons and their infants. [PDF]

open access: yesAJOG Glob Rep
Hsiao A   +11 more
europepmc   +1 more source

Kinetics of SARS‐CoV‐2 Shedding in Nursing Home Residents and Staff

open access: yesJournal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Nursing homes (NHs) were disproportionately affected by the COVID‐19 pandemic. However, little is known regarding the kinetics of SARS‐CoV‐2 shedding in NH residents and staff, which could inform treatment and infection prevention. Methods We enrolled NH residents and staff in eight US states from April to November 2023 and analyzed
Morgan J. Katz   +28 more
wiley   +1 more source

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