Results 161 to 170 of about 967,275 (342)

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Multi-COBRA hemagglutinin formulated with cGAMP microparticles elicits protective immune responses against influenza viruses

mSphere
In humans, seasonal influenza viruses cause epidemics. Avian influenza viruses are of particular concern because they can infect multiple species and lead to unpredictable and severe disease.
Xiaojian Zhang, Hua Shi, Dylan A. Hendy, Eric M. Bachelder, Kristy M. Ainslie, Ted M. Ross   +5 more
doaj   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Production and Immune Response Against Pandemic Influenza Candidate Vaccines as Preparedness Against the Circulating H5N1 Influenza Viruses

Background/Objectives:H5N1 influenza viruses are spreading worldwide and threaten global public health. Preparedness is necessary to mitigate the worst-case scenario should an H5N1 influenza pandemic occur and justify the development of vaccines against ...
Paulo Newton Tonolli, Mahyumi Fujimori, Pollyanna Fernandes Campos, Soledad Palameta, Fernanda de Lima Valadares, Helena Lage Ferreira, Christian Savio Silva, Felipe Catanzaro De Moraes, Ricardo das Neves Oliveira, Vitor Anselmo Sakihara, Fabiana Lauretti Ferreira, Natully de Souza Suffert Fogaça, Douglas Gonçalves de Macedo, Paulo Lee Ho, Alexandre Bimbo, Stephane Tereza Queiroz de Andrade, Edison Luiz Durigon, Daniela Cajado-Carvalho, Patrícia Antonia Estima Abreu, Clarice Weis Arns, Yordanka Medina-Armenteros, Esper George Kallás, Júlia Tavares de Castro, Priscila Comone, Bianca Pereira Carvalho Holanda, Lívia Mendonça Munhoz Dati, Michael Edward Miller, Milena Apetito Akamatsu, Rhubia Silveira Martins Rosa   +28 more
core   +1 more source

Adjuvanted Influenza Vaccines Elicits Higher Antibody Responses against the A(H3N2) Subtype than Non-Adjuvanted Vaccines

, 2020
Background: vaccination is the best approach to prevent influenza infections so far. Serological studies on the effect of different vaccine types are important to address vaccination campaigns and protect our population.
José María Eiros Bouza, Laura Sánchez de Prada, Raúl Ortiz de Lejarazu Leonardo, Iván Sanz Muñoz, Javier Castrodeza Sanz   +4 more
core   +1 more source

What happened after the epidemic? Equine influenza surveillance sheds light on sources and seasonal risk in the United Kingdom

Equine Veterinary Journal, EarlyView.
Abstract Background The epidemiology of equine influenza (EI) in the United Kingdom has not been systematically described since the 2019 epidemic. Objectives To summarise UK EI surveillance (2020–2024), quantify outbreak seasonality and assess movement‐related sources. Study Design Retrospective observational analysis of national surveillance and horse
Fleur Whitlock, John Grewar, Richard Newton   +2 more
wiley   +1 more source

Safety and immunogenicity of AS03B adjuvanted split virion versus non-adjuvanted whole virion H1N1 influenza vaccine in UK children aged 6 months-12 years: open label, randomised, parallel group, multicentre study

, 2010
Objectives: To compare the safety, reactogenicity, and immunogenicity of an adjuvanted split virion H1N1 vaccine and a non-adjuvanted whole virion vaccine used in the pandemic immunisation programme in the United Kingdom.
Sheasby, E, Faust, S N, Okike, I, Miller, E., Casey, M., Walker, W T, Sheasby, E., Waight, P., Ladhani, S., Allen, R.J., Andrews, N, Eccleston, P.E., Faust, S.N., Oeser, C, John, T, Snape, MD, Pollard, AJ, Pollard, Andrew, Finn, A., Casey, M, Waddington, CS, Heath, PT, Heath, P.T., Collinson, AC, Eccleston, P E, Waddington, Claire S, Wilkins, S, Allen, R J, Faust, SN, Walker, W.T., Reiner, A, Ladhani, S, Collinson, A.C., Okike, I., Reiner, A., Waddington, Claire S., Miller, E, Andrews, N., Allen, RJ, Finn, A, Wilkins, S., Snape, M.D., Pollard, A.J., Eccleston, PE, Collinson, A C, Walker, WT, Heath, P T, Snape, M D, Hoschler, K., John, T., Hoschler, K, Waight, P, Oeser, C.   +52 more
core   +1 more source

Health economic considerations for pharmacogenomic services in the United Kingdom: The Centre for Excellence in Regulatory Science and Innovation in Pharmacogenomics

British Journal of Clinical Pharmacology, EarlyView.
Dyfrig A. Hughes, Henry Fong, Grace Hampson, Catrin O. Plumpton, Chris Sampson   +4 more
wiley   +1 more source