Results 211 to 220 of about 968,734 (398)

Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su   +6 more
wiley   +1 more source

Simultaneous vaccination against influenza and respiratory syncytial virus in high‐risk heart failure patients

open access: yesESC Heart Failure, EarlyView.
In a prospective, randomized study of high‐risk HF patients, simultaneous vaccination against influenza and RSV reduced the risk of the primary composite endpoint (hospitalization for HF, all‐cause death, or infection). The main driver of benefit was a lower incidence of infections.
Jan Biegus   +14 more
wiley   +1 more source

Personalized Cancer Immunotherapy Boosted by cGAS‐STING‐Targeted Nanovaccines in Combination With Nutrient Modulation

open access: yesExploration, EarlyView.
The engineered bacteria (2'3'‐cGAMP@E.coli) is designed to synthesize intracellular 2'3'‐cGAMP, enabling the assembly of personalized nanovaccines (nECTs) through a bioconjugation with autologous tumor antigens, circumventing elaborate chemical production processes. The therapeutic impact of nECTs is significantly amplified when combined with a fasting‐
Wenping Huang   +7 more
wiley   +1 more source

Exploring Plant‐Derived Nutraceuticals as Potential SARS CoV‐2 Mpro Inhibitors

open access: yesFood Chemistry International, EarlyView.
The search for plant derived anti‐SARS‐CoV‐2 Mpro compounds starts from food plants and spices as rich sources of bioactive compounds. Both in silico screening and experimental validation are essential to assess their therapeutic potential, leading to candidates for drug development and dietary integration.
Shaza S. Issa, Tatiana V. Matveeva
wiley   +1 more source

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