Results 241 to 250 of about 211,619 (334)
The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging
Aging Cell, EarlyView.Human aging shows puzzling diversity: similar aging rates yet vastly different health outcomes. Our study of ~17,500 people revealed a health‐promoting trait (more common in women) linked to strong immune resilience and high expression of TCF7, a key immune gene. This trait enables individuals to fight infections like COVID‐19 more effectively, respond Muthu Saravanan Manoharan, Grace C. Lee, Nathan Harper, Justin A. Meunier, Marcos I. Restrepo, Fabio Jimenez, Sreenath Karekatt, Anne P. Branum, Alvaro A. Gaitan, Kian Andampour, Alisha M. Smith, Michael Mader, Michelle Noronha, Devjit Tripathy, Nu Zhang, Alvaro G. Moreira, Lavanya Pandranki, South Texas Veterans Health Care System (STVHCS) COVID‐19 Clinical team, STVHCS COVID‐19 Vaccine team, STVHCS COVID‐19 Convalescent care team, STVHCS Center for Personalized Medicine, Sandra Sanchez‐Reilly, Hanh D. Trinh, Clea Barnett, Luis Angel, Leopoldo N. Segal, Susannah Nicholson, Robert A. Clark, Weijing He, Jason F. Okulicz, Sunil K. Ahuja, Andrew Carrillo, Chanda Dhami, Gaeun Jo, Krupa Jiva, Ernesto Robinson, Caitlyn A. Winter, Lauryn A. Winter, Erin Stewart, Joseph M. Yabes, Peter Melby, Cody R. Butler, Mohamed I. Abdalla, Sandra G. Adams, Yemi Adebayo, Joseph Agnew, Saleem Ali, Gregory Anstead, Antonio Anzueto, Marichu Balmes, Jennifer Barker, Raymond Benavides, Velma Bible, Angela Birdwell, Stacy Braddy, Stephen Bradford, Heather Briggs, Jose A. Cadena Zuluaga, Judith Marin‐Corral, Jennifer J. Dacus, Patrick J. Danaher, Scott A. DePaul, Jill Dickerson, Jollynn Doanne, Samantha Elbel, Miguel Escalante, Corina Escamilla, Valerie Escamilla, Robert Farrar, David Feldman, Debra Flores, Julianne Flynn, Delvina Ford, Joanna D. Foy, Megan Freeman, Samantha Galley, Jessica Garcia, Maritza Garza, Sherraine Gilman, Melanie Goel, Jennifer Gomez, Varun K. Goyal, Sally Grassmuck, Susan Grigsby, Joshua Hanson, Brande Harris, Audrey Haywood, Joan M. Hecht, Cecilia Hinojosa, Tony T. Ho, Teri Hopkins, Aneela N. Hussain, Ali Jabur, Pamela Jewell, Thomas B. Johnson, Austin C. Lawler, Monica Lee, Chadwick S. Lester, Stephanie M. Levine, Haidee V. Lewis, Angel Louder, Charmaine Mainor, Rachel Maldonado, Celida Martinez, Yvette Martinez, Chloe Mata, Neil McElligott, Laura Medlin, Myra Mireles, Joanna Moreno, Kathleen Morneau, Julie Muetz, Samuel B. Munro, Charlotte Murray, Anoop Nambiar, Daniel Nassery, Robert Nathanson, Kimberly Oakman, Jane O’Rorke, Cheryl Padgett, Sergi Pascual‐Guardia, Marisa Patterson, Graciela L. Perez, Rogelio Perez, Jay I. Peters, Rogelio Perez III, Robert E. Phillips, Patrick B. Polk, Michael A. Pomager, Kristy J. Preston, Kevin C. Proud, Jacqueline A. Pugh, Michelle Rangel, Temple A. Ratcliffe, Renee L. Reichelderfer, Evan M. Renz, Jeanette Ross, Teresa Rudd, Maria E. Sanchez, Tammy Sanders, Kevin C. Schindler, David Schmit, Raj T. Sehgal, Claudio Solorzano, Nilam Soni, Win S. Tam, Edward J. Tovar, Sadie A. Trammell Velasquez, Anna R. Tyler, Anjuli Vasquez, Maria C. Veloso, Steven G. Venticinque, Jorge A. Villalpando, Melissa Villanueva, Lauren Villegas, Megan Walker, Andrew Wallace, Maria Wallace, Emily Wang, Stephanie Wickizer, Andreia Williamson, Andrea Yunes, Katharine H. Zentner, Azaneth Arellanes, Ashley B. Banfield, Stephanie N. Bolan‐Reding, Roxanne Colazo, Katherine S. DeLeon, Norma G. Diaz, Mario A. Garza, Raed Kadhume, Hue Mang, Erwin Paleracio, Robert F. Quitta, Laura J. Ramirez, Marzieh Salehi, Cynthia J. Varela +176 morewiley +1 more sourceFreeze-drying of live virus vaccines : a review [PDF]
, 2015 Daoussi, R, De Beer, Thomas, Hansen, Laurent, Remon, Jean Paul, Vervaet, Chris +4 morecore +2 more sourcesImmunosenescence Profile Is Associated With Increased Susceptibility to Severe COVID‐19
Aging Cell, EarlyView.(A) A previous immunosenescence profile in individuals infected with SARS‐CoV2 creates a permissive environment for progression to severe COVID‐19: higher inflammaging, accumulation of exhausted/senescent T cells, an oligoclonal B‐cell repertoire, and accelerated epigenetic age.Lucas Haniel A. Ventura, Lícia Torres, Giovanna Caliman Camatta, Jofer Zamame, Monique Macedo Coelho, Cecília Horta Ramalho‐Pinto, João Gervazio, Felipe Caixeta, Leandro Nascimento, Mariana Almeida Oliveira, Vinícius Dantas Martins, Marcos Felipe Oliveira, Murilo Soares Costa, Hugo Itaru Sato, Henrique Cerqueira Guimarães, Rafael Calvão Barbuto, Ana Paula Rocha Veiga, Najara Ataíde, Gabriela Prandi Caetano, Sarah Rangon, Mauro Lúcio O. Júnior, Fernanda Calvo Fortes, Luciana Zuccherato, Elaine Speziali, Olindo Assis Martins‐Filho, Verônica Coelho, Roberto Avritchir, Rafael Souza, Marina Ayupe, Caio Loureiro, Maria Eduarda Passos, Ana Clara Mota Neves, Pauline Leite, Santuza Maria Ribeiro Teixeira, Unaí Tupinambás, Liza Figueiredo Felicori, Gabriela Silveira‐Nunes, Tatiani Uceli Maioli, Denise Morais Fonseca, Andrea Teixeira‐Carvalho, Ana Maria Caetano Faria +40 morewiley +1 more sourceBoosting neuraminidase immunity in the presence of hemagglutinin with the next generation of influenza vaccines. [PDF]
NPJ VaccinesCortés G, Ustyugova I, Farrell T, McDaniel C, Britain C, Romano C, N'Diaye S, Zheng L, Ferdous M, Iampietro J, Pougatcheva S, La Rue L, Han L, Ma F, Stegalkina S, Ray S, Zhang J, Barro M. +17 moreeuropepmc +1 more sourceAging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8+ T Cells Responding to Coronavirus Infection
Aging Cell, EarlyView.In a MHV infection model with age‐associated increased mortality, we demonstrate that aging impairs, instead of promoting, the terminal differentiation program of virus‐specific CD8+ T cells through downregulating key transcriptional regulators of terminal differentiation.Ziang Zhu, Guohua Lou, Ying Luo, Kiddist Yihunie, Jonathan Hoar, Juan A. Daniel, Bret M. Evers, Chen Yao, Tuoqi Wu +8 morewiley +1 more source