Results 141 to 150 of about 2,123,414 (312)

Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity

Advanced Science, EarlyView.
The axon initial segment (AIS), crucial for action potential initiation, serves as a prime locus for controlling network activity. Chandelier Cells (ChCs), evolved in the mammals, intricately target AISs, acting as gatekeepers for neuronal firing. Diminishing ChC input makes animals more prone to developing seizures, whereas fortifying this connection ...
Yang Li, Jifeng Tian, Jiafan Wei, Qianyun Wang, Jiaxu Ge, Jianguang Ni, Jiangteng Lu, Yilin Tai   +7 more
wiley   +1 more source

Household Transmission of Influenza A Viruses in 2021-2022 [PDF]

, 2023
Melissa A. Rolfes, H. Keipp Talbot, Huong Q. McLean, Melissa S. Stockwell, Katherine Ellingson, Karen Lutrick, Natalie M. Bowman, Emily E. Bendall, Ayla Bullock, James D. Chappell, Jessica E. Deyoe, Julie Gilbert, Natasha Halasa, Kimberly E. Hart, Sheroi Johnson, Ahra Kim, Adam S. Lauring, Jessica T. Lin, Christopher J. Lindsell, Son H. McLaren, Jennifer K. Meece, Alexandra M. Mellis, Miriana Moreno Zivanovich, Constance Ogokeh, Michelle Rodriguez, Ellen Sano, Raul A. Silverio Francisco, Jonathan E. Schmitz, Celibell Vargas, Amy Yang, Yuwei Zhu, Edward A. Belongia, Carrie Reed, Carlos G. Grijalva   +33 more
openalex   +1 more source

Inhibiting Liver‐Derived C3 Protein Rescues Anesthesia/Surgery‐Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis

Advanced Science, EarlyView.
This study provides evidence that anesthesia/surgery can induce the BBB breakdown and promote the release of hepatogenous C3 protein into the blood. This surgical dual factors ultimately drove C3 to cross the damaged BBB and selectively colocalize with C3aR in the hippocampus, which results in structural and functional injury of synapse, C3aR‐mediated ...
Qianqian Wu, Peilin Cong, Zhouxiang Li, Yuxin Zhang, Huanghui Wu, Qian Zhang, Yawei Li, Li Tian, Qingyuan Miao, Yinggang Zheng, Hui Zhang, Qian Chen, Enduo Feng, Xinyang Li, Zheping Chen, Dong‐Xin Wang, Xinwei Huang, Lize Xiong   +17 more
wiley   +1 more source

2P290 Single particle detection of influenza virus by micro droplet array(26. Measurements,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))

, 2014
Shuho Kidokoro, Kazuhito V. Tabata, H. Noji   +2 more
openalex   +2 more sources

Interaction of influenza A virus with human peripheral blood lymphocytes [PDF]

, 1979
J. M. Brownson, Brian W. J. Mahy, B L Hazleman   +2 more
openalex   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

Influenza a Virus Inhibition: Evaluating Computationally Identified Cyproheptadine Through In Vitro Assessment [PDF]

Sanja Glišić, Kristina Stevanović, Andrej Perdih, Natalya Bukreyeva, Junki Maruyama, Vladimir Perović, Sergi López-Serrano, Ayub Darji, Draginja Radošević, Milan Senćanski, Veljko Veljković, Bruno Botta, Mattia Mori, Slobodan Paessler   +13 more
openalex   +1 more source

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source

Sanggenol L Enhances Temozolomide Drug Sensitivity by Inhibiting Mitophagy and Inducing Apoptosis Through the Regulation of the TRIM16‐OPTN Axis in Glioblastoma

Advanced Science, EarlyView.
Sanggenol L, a flavonoid from mulberry, enhances glioblastoma sensitivity to temozolomide by inhibiting mitophagy and inducing apoptosis through TRIM16‐mediated OPTN degradation. In animal studies, liposomal delivery of Sanggenol L significantly improves the efficacy of its combination with TMZ, providing new insights into glioblastoma treatment ...
Hongbo Chang, Jianbing Hou, Xin Hu, Nana Hou, Minghao Xu, Yi Du, Jingyang Xu, Yongzhao Wang, Zhuohao Xie, Junbo Shi, Yundong Zhang, Hongjuan Cui   +11 more
wiley   +1 more source

Impaired early type I interferon responses to influenza virus infection in aged mice are associated with subsequent increased pulmonary inflammation [PDF]

Wenxin Wu, Jeremy S. Alexander, J. Leland Booth, Chaoqun Huang, Lin Liu, Craig Miller, Douglas A. Drevets, Jordan P. Metcalf   +7 more
openalex   +1 more source