Results 151 to 160 of about 343,579 (311)

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

Validation of H5 influenza virus subtyping RT-qPCR assay and low prevalence of H5 detection in 2024-2025 influenza virus season. [PDF]

J Clin Microbiol
Bacsik DJ, Mills MG, Monroe LD, Spring C, Perez-Osorio AC, Reed JC, Fang FC, Bourassa L, Roychoudhury P, Crawford KHD, Snekvik K, Greninger AL.   +11 more
europepmc   +1 more source

Immunogenicity, Boostability, and Sustainability of the Immune Response after Vaccination against Influenza A Virus (H1N1) 2009 in a Healthy Population

, 2011
Elisabeth G. W. Huijskens, John W. A. Rossen, Paul Mulder, Ruud van Beek, Hennie van Vugt, Johannes Verbakel, Guus F. Rimmelzwaan, Marion Koopmans, Marcel F. Peeters   +8 more
openalex   +1 more source

Validating International Classification of Disease 10th revision algorithms for identifying influenza and respiratory syncytial virus hospitalizations

, 2021
Mackenzie A. Hamilton, Andrew Calzavara, Scott D. Emerson, Jeffrey C. Kwong   +3 more
openalex   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Development of Nanobody-Expressing Nanosomes for Neutralization of Influenza Virus. [PDF]

J Microbiol Biotechnol
Kim T, Jang IH, Shin S, Kang J, Ahn HJ, Moon S, Kim J, Ryu JH, Lee KA.   +8 more
europepmc   +1 more source

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

A multivalent nanobody-drug conjugate to prevent and treat influenza virus infections. [PDF]

Proc Natl Acad Sci U S A
Harmand TJ, Pietrok L, Rich H, Deshycka R, Flanagan L, Accardo A, Pishesha N, Ploegh HL.   +7 more
europepmc   +1 more source

Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction

, 2018
Ilaria D’Agostino, Ilaria Giacchello, Giulio Nannetti, Anna Lucia Fallacara, Davide Deodato, Francesca Musumeci, Giancarlo Grossi, Giorgio Palù, Ylenia Cau, Iuni Margaret Laura Trist, Arianna Loregian, Silvia Schenone, Maurizio Botta   +12 more
openalex   +2 more sources