Results 191 to 200 of about 2,123,414 (312)

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Co-injection with inactivated <i>Enterococcus faecium</i> and inactivated H1N1 influenza virus intravenously strengthen the protection of H1N1 influenza virus infections in mice. [PDF]

Front Microbiol
Li J, Ren Y, Xue M, Shao D, Zhuang L, Shen Z, Tang Z, Cui Y, Shi Y.   +8 more
europepmc   +1 more source

Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E

Advanced Science, EarlyView.
Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple models, secondary necrosis occurred regardless of gasdermin E presence, challenging prior claims and redefining the understanding of how apoptotic cells ...
Shubhangi Gavali, Francesca Maremonti, Wulf Tonnus, Florian Gembardt, Marlena Nastassja Schlecht, Karolin Flade, Anne von Mässenhausen, Stephen W. G. Tait, Stefan R. Bornstein, Andreas Linkermann   +9 more
wiley   +1 more source

Metabolic Hostile Takeover: How Influenza Virus Reprograms Cellular Metabolism for Replication. [PDF]

Viruses
Hui X, Tian X, Ding S, Gao G, Zhao X, Cui J, Hou Y, Zhao T, Wang H.   +8 more
europepmc   +1 more source

Disease of influenza virus and SARS‐CoV‐2 coinfection: Flurona or Flucovid?

, 2022
Shuwen Liu, Weihua Li, Shibo Jiang
openalex   +2 more sources

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

Advanced Science, EarlyView.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
wiley   +1 more source

Gastrointestinal Infiltration in Influenza Virus Infection: Mechanisms and Clinical Insights. [PDF]

Viruses
Dua A, Trehan B, Bilasy SE, Yang C, ElShamy A.   +4 more
europepmc   +1 more source

Characterization and mechanisms of anti-influenza virus metabolites isolated from the Vietnamese medicinal plant Polygonum chinense [PDF]

, 2017
Thu Thi Tran, Meehyein Kim, Yejin Jang, Hye Won Lee, Hoa Thi Nguyen, Thanh Ngoc Nguyen, Hae Woong Park, Quang Lê Đăng, Jin‐Cheol Kim   +8 more
openalex   +1 more source

Long-term Epidemiology and Evolution of Swine Influenza Viruses, Vietnam

, 2023
Jonathan Tin Lai Cheung, Anh Ngoc Bui, Sonia Younas, Kimberly M. Edwards, Huy Nguyen, Pham Thi Ngoc, Vuong Nghia Bui, Malik Peiris, Dhanasekaran Vijaykrishna   +8 more
openalex   +1 more source

Integrating Single‐Cell Transcriptome‐Wide Mendelian Randomization and Differentially Expressed Gene Analyses to Prioritize Dynamic Immune‐Related Drug Targets for Cancers

Advanced Science, EarlyView.
Inspired by evidence triangulation, a new sensitivity method called MR‐DEG is developed, which uses the differentially expressed gene (DEG) results as additional evidence to minimize pleiotropic effects and strengthen Mendelian randomization (MR) causal estimates. Using dynamic single‐cell expression quantitative trait loci (eQTLs) as an example, it is
Jie Zheng, Qian Yang, Haoyu Liu, Huiling Zhao, Shuangyuan Wang, Yi Liu, Xueyan Wu, Yilan Ding, Hui Ying, Youqiu Ye, Xi Huang, Lei Ye, Ruizhi Zheng, Hong Lin, Mian Li, Tiange Wang, Zhiyun Zhao, Min Xu, Yi Duan, Hao Guo, Zhongshang Yuan, Philip Haycock, George Davey Smith, Richard M Martin, Guang Ning, Fang Hu, Weiqing Wang, Tom R. Gaunt, Jieli Lu, Yufang Bi   +29 more
wiley   +1 more source