Results 201 to 210 of about 343,579 (311)

Modeling of H5N1 influenza virus kinetics during dairy cattle infection suggests the timing of infectiousness. [PDF]

PLoS Biol
Eales O, McCaw JM, Shearer FM.
europepmc   +1 more source

CRISPR in MOF Formulation with Enhanced Stability, Activity, and Altered PAM Specificity for Broad‐Spectrum Diagnosis of Bacterial Sepsis

Advanced Science, EarlyView.
CRISPR‐FLEXMO (CRISPR with flexible PAM in MOF encapsulation) integrates a PAM‐relaxed Cas12a K607R enzyme with a manganese‐coordinated MOF for broad‐spectrum diagnosis of bacterial sepsis. The MOF enhances activity and preserves functionality under heat, solvent, and chaotropic stress, supporting long‐term room‐temperature storage.
Tathagata Pal, Zilong Liu, Meera G. Nair, Juhong Chen   +3 more
wiley   +1 more source

Interim vaccine effectiveness against influenza virus among outpatients, France, October 2025 to January 2026. [PDF]

Euro Surveill
De Clercq A, Blanquart F, Vieillefond V, Visseaux B, Jacques A, Haim-Boukobza S, Wehrle V, Deleglise G, Duret T, Bernard-Stoecklin S, Perez-Bercoff D, Oblette A, Lina B, Rameix-Welti MA, Josset L, Enouf V, Bal A, RELAB study group.   +17 more
europepmc   +1 more source

Behavior‐ and Cell Type‐Specific Cortico‐Striatal Decoupling in a Parkinson's Disease‐Like Mouse Model

Advanced Science, EarlyView.
Utilizing dual‐site fiber photometry, this study examines cortico‐striatal coupling with cell type resolution, identifying behavior‐ and cell type‐specific cortico striatal decoupling and its dopamine‐dependent mechanism in a Parkinson's disease mouse model.
Xu‐Ran Yao, Yang Liu, Wei‐Tong Zheng, Mao‐Qing Huang, Kai‐Wen He   +4 more
wiley   +1 more source

Chicken PIAS2 enhances H6N2 avian influenza virus replication by promoting SUMOylation of viral NP. [PDF]

Vet Res
Zhang J, Xue Q, Wang X, Yang H, Huang M, Zhang M, Zhao L, Wang W, Chen Z, Jiao P.   +9 more
europepmc   +1 more source

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Co-injection with inactivated <i>Enterococcus faecium</i> and inactivated H1N1 influenza virus intravenously strengthen the protection of H1N1 influenza virus infections in mice. [PDF]

Front Microbiol
Li J, Ren Y, Xue M, Shao D, Zhuang L, Shen Z, Tang Z, Cui Y, Shi Y.   +8 more
europepmc   +1 more source

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source

Low-replication influenza virus mediates high pathogenicity through an inflammation-driven lung-heart-brain axis in mice. [PDF]

Emerg Microbes Infect
Zhu W, Xu Z, Wang X, Li X, Li Z, Dong G, Yang L, Zhang Y, You R, Peng Y, Wang D.   +10 more
europepmc   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source