Results 61 to 70 of about 4,718,637 (273)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Informant reported cognitive decline in older adults [PDF]
, 2017 Objectives: Gaining an informant’s perspective on cognitive decline has become an increasingly popular, and recommended practice, in the assessment of dementia. However, concern regarding the accuracy of such reports has been documented.
Morrell, L.
core
On Matrix Factorization and Scheduling for Finite-Time Average-Consensus [PDF]
, 2010 We study the problem of communication scheduling for finite-time average-consensus in arbitrary connected networks. Viewing this consensus problem as a factorization of 1/n 11T by network-admissible families of matrices, we prove the existence of finite
Ko, Chih-Kai
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Journal of Ethnobiology and EthnomedicineBackground Urban markets serve as crucial centres for trading traditional medicinal plants, yet there is limited research on the diversity, geographic origins, and socio-economic contributions of these plants. Therefore, this study aimed at understanding
Justice Muvengwi, Monicah Mbiba
doaj +1 more source
Acta Biologica SlovenicaCompared to other coastal regions of India, research on the quantitative approach of ethnoveterinary useful plants is still scarce in the northeastern coastal region of Odisha.
Keshari Prasad Mohanty +3 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The relationship of dementia prevalence in older adults with intellectual disability (ID) to age and severity of ID [PDF]
, 2009 Background: Previous research has shown that adults with intellectual disability (ID) may be more at risk of developing dementia in old age than expected. However, the effect of age and ID severity on dementia prevalence rates has never been reported. We
Hassiotis, A. +3 more
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
British Journal of Sports MedicineTo (1) systematically review the literature to identify which match-related risk factors and mechanisms of rugby tackle events result in musculoskeletal injury, concussion, head injury assessments, and head impacts or head accelerations; and (2) identify the perceived importance and feasibility of potential intervention strategies for tackle-related ...
Mike Hopkinson +13 more
openaire +4 more sources