Results 131 to 140 of about 550,353 (340)

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

open access: yesAdvanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi   +5 more
wiley   +1 more source

Characterizing Informatics Roles and Needs of Public Health Workers

open access: green, 2015
Brian E. Dixon   +4 more
openalex   +2 more sources

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

open access: yesAdvanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi   +10 more
wiley   +1 more source

AI‐Driven Acceleration of Fluorescence Probe Discovery

open access: yesAdvanced Science, EarlyView.
We present PROBY, an AI model trained on large‐scale datasets to predict key photophysical properties and accelerate the discovery of target‐specific fluorescent probes. By screening a target‐annotated library, PROBY identifies candidate probes for diverse targets and could guide probe optimization, enabling a range of in vitro and in vivo imaging ...
Xuefeng Jiang   +18 more
wiley   +1 more source

Polymer Informatics: Current Status and Critical Next Steps [PDF]

open access: yesMaterials Science and Engineering: R: Reports, 2020
Lihua Chen   +6 more
semanticscholar   +1 more source

Medical informatics [PDF]

open access: yesBMJ, 1995
R, Jones, S, Kinn, F, Grainger
openaire   +2 more sources

OBUSight: Clinically Aligned Generative AI for Ophthalmic Ultrasound Interpretation and Diagnosis

open access: yesAdvanced Science, EarlyView.
OBUSight, a clinically aligned generative AI model that jointly generates reports and predicts diseases through multimodal semantic alignment, was trained and validated on a large multicenter dataset. OBUSight outperformed eight state‐of‐the‐art models, provided clinically reliable reports, enhanced diagnostic efficiency, and achieved performance ...
Xiaocong Liu   +17 more
wiley   +1 more source

PS1-28: Optimizing Health Informatics Interventions From the Patient's Perspective: Focus Group on Improving Safe NSAID Use [PDF]

open access: hybrid, 2010
D. Roblin   +5 more
openalex   +1 more source

Environmental informatics [PDF]

open access: yesEnvironmental Modelling & Software, 2006
Hilty, Lorenz M   +2 more
openaire   +1 more source

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