Results 101 to 110 of about 1,459,315 (301)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Cloud Framework for the Networked Expert and Analytical Tools Integration

open access: yesТруды Института системного программирования РАН, 2018
Information-analytical decision support systems in government and business are distributed. There are two substantially different approaches of information, experts and analytical support of decision-making.
A. . Ermakov   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Funding of development projects by Learning and Teaching Support Network - Centre for Information and Computer Sciences [PDF]

open access: yes, 2001
The Learning and Teaching Support Network was established at the beginning of the year 2000 by the higher education funding bodies. It is intended to provide an integrated network of subject centres to enhance learning and teaching activity in UK higher ...
Brine, Alan
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Facilitating independence: The benefits of a post-diagnostic support project for people with dementia.

open access: yes, 2014
Providing support in the form of information, advice and access to services or social events is promoted as beneficial for people newly diagnosed with dementia and their families. This paper reports on key findings from an evaluation of a post-diagnostic
Innes, Anthea, Kelly, Fiona
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Preferance of computer technology for analytical support of large database of medical information systems [PDF]

open access: yesСаратовский научно-медицинский журнал, 2013
Aim: to study the use of intelligent technologies for analytical support of large databases of medical information systems. Material and methods. We used the techniques of object-oriented software design and database design. Results.
Biryukov А.P.   +5 more
doaj  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Determinants of knowledge management with information technology support impact on firm performance. Information Technology and Management

open access: yes, 2013
[[abstract]]The relationship between knowledge management (KM) and firm performance has been the subject of discussion in management literature. However, certain studies have found a significant link between KM and firm performance, whereas others have ...
莊淑惠;Shu-Hui Chuang;Chechen Liao;Shinyi Lin
core  

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