Results 111 to 120 of about 2,365,288 (278)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Preferance of computer technology for analytical support of large database of medical information systems [PDF]

Саратовский научно-медицинский журнал, 2013
Aim: to study the use of intelligent technologies for analytical support of large databases of medical information systems. Material and methods. We used the techniques of object-oriented software design and database design. Results.
Biryukov А.P., Vasiliev E.V., Dumansky S.М., Tikhonova О.A., Gert Ju.A., Kapitonova N.V.   +5 more
doaj  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Information-analytical support of convoy service and combat tasks

Honor and Law
Existing tendencies to building the information-analytical support system of law enforcement agencies and the Interior Troops in conducting convoy service and combat tasks are considered.Approaches to obtaining official information necessary for administrative activities are suggested.
Yermoshin, М. О., Kyrylenko, V. А.
openaire   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

The risks of multiple breadbasket failures in the 21st century: a science research agenda [PDF]

, 2017
Thomson ReutersThis report stems from an international, interdisciplinary workshop organized by Knowledge Systems for Sustainability and hosted by the Frederick S. Pardee Center for the Study of the Longer-Range Future, with support from Thomson Reuters,
Glauber, Joseph, Jahn, Molly, Janetos, Anthony, Justice, Christopher, Mulhern, William, Obersteiner, Michael   +5 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Information and analytical support of scientific mass events using electronic social networks [PDF]

У публікації розглянуто можливості використання електронних соціальних мереж для інформаційно-аналітичної підтримки наукових масових заходів.В публикации рассмотрены возможности использования электронных социальных сетей для информационно-аналитической ...
Яцишин, А.В.
core  

Role of the library and information products in answering the information needs of public authorities (on the example of Vernadsky National Library of Ukraine) [PDF]

, 2015
Розглянуто роль бібліотечно-інформаційних продуктів в інформаційній підтримці органів державної влади. Зокрема, розглянута діяльність Служби інформаційно- аналітичного забезпечення (СІАЗ) Національної бібліотеки України імені В. І.
Prysiazhna, L., Присяжна, Л. В.   +1 more
core