Results 181 to 190 of about 22,983,555 (247)

A sequential integrating virtual simulation and authentic video for preschool teacher candidates' observational skills training: A design-based intervention study. [PDF]

PLoS One
Zhang B, Gou S, Wang D, Zhu X, Han Y, Sun Y, Li Y, Hu Q, Liu X.   +8 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Federated analytics for non-communicable disease surveillance in the European health data space: a scoping review and conceptual framework. [PDF]

Front Public Health
Carinci F, Fava S, Štotl I, Nicholson N.   +3 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Behavioral Barriers to Digital Health and Conditions of Digital Resilience Among Older Adults: Evidence from China. [PDF]

Behav Sci (Basel)
Ren Y, Yang W, Li W.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

"Do not leave me behind and do not put me in your box": family-planning access and care needs among women with migration histories in Berlin, Germany-a mixed-methods study. [PDF]

Reprod Health
Hassantabar B, Kovane GP, Riya NJA, Woks NIE, Fasina MM, Sehouli J, Leinweber J, Phuti A.   +7 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Paediatric Scalp-Hair Biomonitoring of Nutritionally Relevant and Mixed-Source Elements in Urban-Industrial Spain. [PDF]

J Xenobiot
Peña-Fernández A, Peña Fernández MÁ, Martínez-Alonso B, Moreno-Gómez-Toledano R, Cámara-Pastor T, Higueras M, Lobo-Bedmar MC.   +6 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source