Results 111 to 120 of about 39,749,831 (352)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Galaxy And Mass Assembly (GAMA): refining the local galaxy merger rate using morphological information [PDF]

, 2014
Kevin Casteels, Christopher J. Conselice, S. P. Bamford, Eduard Salvador-Solé, P. Norberg, N. K. Agius, I. K. Baldry, Sarah Brough, M. J. I. Brown, M. J. Drinkwater, Simon P. Driver, Alister W. Graham, Joss Bland‐Hawthorn, Andrew Hopkins, L. S. Kelvin, Á. R. López-Sánchez, J. Loveday, A. S. G. Robotham, J. A. Vázquez-Mata   +18 more
openalex   +1 more source

Maximizing information from chemical engineering data sets: Applications to machine learning

, 2022
Alexander Thebelt, Johannes Wiebe, Jan Kronqvist, Calvin Tsay, Ruth Misener   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Backmatter

Jurnal Teknik Industri, 2017
Editorial Information
doaj   +3 more sources

Visual working memory buffers information retrieved from visual long-term memory [PDF]

, 2017
Keisuke Fukuda, Geoffrey F. Woodman
openalex   +1 more source

INSPIRAL: investigating portals for information resources and learning. Final project report [PDF]

, 2001
INSPIRAL's aims were to identify and analyse, from the perspective of the UK HE learner, the nontechnical, institutional and end-user issues with regard to linking VLEs and digital libraries, and to make recommendations for JISC strategic planning and ...
Brown, S., Currier, S., Ekmekioglu, F.C., JISC (Joint Information Systems Committee) (Funder)   +3 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

“Informed Informants”

Abstract Former extremists have been employed widely in the field of preventing and countering violent extremism (P/CVE) for several decades. The underlying assumption for their involvement in P/CVE was, and continues to be, the potentially higher levels of milieu-specific knowledge, personal experience, and expertise in detecting and ...
openaire   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source