Results 111 to 120 of about 24,603,743 (269)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Abstract Former extremists have been employed widely in the field of preventing and countering violent extremism (P/CVE) for several decades. The underlying assumption for their involvement in P/CVE was, and continues to be, the potentially higher levels of milieu-specific knowledge, personal experience, and expertise in detecting and ...
openaire +1 more source
Authority of the State Chief Information Officer to Establish Ohio IT Policy
, 2020 [05/21/2020 revision]; "Statewide Policy."; "Effective: May 21, 2020."; "Revision history ... 10/13/2016, Updated to reflect changes in procurement authority. ... Re-numbered policy to IT-01 to be consistent with new numbering format; 05/21/2020, Updated
Ohio. Office of Information Technology
core
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Information, Vatican: Current Crisis Calls for World Financial Reorganisation
Problemy Ekorozwoju, 2010 In the Vatican’s Clementine Hall the Holy Father Benedict XVI received members of the Union of Industrialists and Businesses of Rome. Opening his remarks to them with a reference to the current economic crisis, the Pope noted how it has sorely tried the
Vatican Information Service
doaj
Information Systems Implementation Failure: Insights from Prism
, 2008 10.1016/j.ijinfomgt.2007.07.001International Journal of Information Management284259 ...
PAN, Shan Ling +5 more
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source