Results 121 to 130 of about 5,266,549 (288)
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Owner and Contractor Perceptions Toward Factors Causing Delays in Structural and Finishing Works
A construction project comprises of a number of work packages, which are subjected to delays. These delays may be caused by many on-site factors. The aim of this research is to represent owner and contractors perceptions towards delay factors that ...
Loanata V.R., Lalitan D., Andi A.
doaj
Mechanisms of parasite‐mediated disruption of brain vessels
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Equivariant infinite loop space theory, I. The space level story
We rework and generalize equivariant infinite loop space theory, which shows how to construct G-spectra from G-spaces with suitable structure. There is a naive version which gives naive G-spectra for any topological group G, but our focus is on the ...
May, J. Peter +2 more
core
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
The Decision of Information Safety Problems at Processing of the Biometric Personal Data
The requirements imposed on transfer by the personal biometric information in systems and communication networks according to Federal Law № 152 “Personal data” are defined.
Y. G. Gorshkov
doaj
A general framework for information-work interconvertibility in the quantum regime
Description: In the context of quantum thermodynamics the Landauer's principle and the Szilard engine are usually presented as the paradigmatic examples of the inter-convertibility between information and work. Besides, the fluctuation-dissipation theorems (Jarzynski and Crooks equalities) take into account the quantum effects in work extraction.
openaire +1 more source
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source

