Results 71 to 80 of about 3,511 (191)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

The dispute over Elżbieta Zawacka – the soldier and educationalist

open access: yesRocznik Andragogiczny, 2015
The author appreciatively welcomes the release of a new work by Katarzyna Minczykowska Cichociemna. Generał Elżbieta Zawacka „Zo” devoted to the biography, military and scientific merit of Elżbieta Zawacka – the teacher, soldier, the professor and the ...
Józef Półturzycki
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Decistifying trans and gender diverse inclusion in library work: A literature review

open access: yesIn the Library with the Lead Pipe
This comprehensive review illuminates the current state of scholarly literature on trans and gender diverse inclusion in libraries…Covering 50 works published between 2002 and 2023 in the areas of general inclusion, public libraries, academic libraries ...
Keahi Adolpho, Stephen G. Krueger
doaj  

WHAT IS INSIDE A PROBABILISTIC EXPERT SYSTEM

open access: yesRatio Mathematica, 1995
This paper is an outline of how a probabilistic expert system works, therefore the theoretical details have been omitted. They have been widely dealt with e. g. in the quoted references. The framework is the one of de Finetti’s theory.
Giuseppe Di Biase
doaj  

Kazakh khans of the 15th–17th centuries in the scientific heritage of Shigabutdin Marjani

open access: yesЗолотоордынское обозрение
Research objectives: The consideration of information about the Kazakh khans of the 15th–17th centuries, contained in the scientific heritage of Shihabutdin Marjani. Research materials: Sh.
Atygayev N.A.
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy