Results 161 to 170 of about 32,700,272 (303)

Learned foveal representations, not gaze-mediated information access, underlie perceptual advantages for canonical face configurations. [PDF]

J Vis
Chakravarthula PN, Tsank Y, Eckstein MP.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A qualitative exploration of information access and provision for cancer survivors experiencing chronic bowel symptoms after pelvic radiotherapy: informing a framework to guide improvements to information provision. [PDF]

Support Care Cancer
Biran A, Dobson C, Maybury J, Rees CJ, Brooks-Pearson R, Cunliffe A, Durrant L, Hancock J, Neilson LJ, Wilson A, Sharp L.   +10 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Listening to Australians with ovarian cancer: a cross-sectional survey investigating clinical trials awareness, information access and participation. [PDF]

Support Care Cancer
Williams N, Lee YC, Russell H, Andrews J, Chen WS, Bradhurst B.   +5 more
europepmc   +1 more source

Information Access and Use by Patients With Cancer and Their Friends and Family: Development of a Grounded Theory. [PDF]

J Med Internet Res, 2020
Thiessen M, Sinclair S, Tang PA, Raffin Bouchal S.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cervical cancer information access and dissemination strategies among rural Kenyan women: A mixed methods study. [PDF]

J Public Health Afr
Chepkorir J, Kivuti-Bitok L, Perrin N, Gross D, Gallo JJ, Anderson J, Reynolds NR, Wyche S, Kibet H, Kipkuri V, Cherotich A, Guillaume D, Han HR.   +12 more
europepmc   +1 more source

Parental Online Information Access and Childhood Vaccination Decisions in North America: Scoping Review. [PDF]

J Med Internet Res, 2020
Ashfield S, Donelle L.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source