Results 41 to 50 of about 2,024,077 (294)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

INNOVATIVE METHODS OF EVALUATING THE EFFICIENCY OF ADVERTISING ACTIVITIES WITHIN THE FRAMEWORK OF DIGITAL STRATEGY (ON THE EXAMPLE OF «NOVA POST LLC»)

Економіка та суспільство
The article provides a comprehensive analysis of the evolution of methods for evaluating advertising effectiveness in the context of digital transformation and the growing role of data-driven decision-making. The limitations of traditional metrics (ROI,
Ольга Ромащенко, Павлов Павлов, Анастасія Свиридюк   +2 more
doaj   +1 more source

3D Visualization of Sound Fields Perceived by an Acoustic Camera

Cybernetics and Information Technologies, 2015
The paper summarizes the application results of a recently proposed neuro-fuzzy algorithm for multi-dimensional data clustering to 3-Dimensional (3D) visualization of dynamically perceived sound waves recorded by an acoustic camera. The main focus in the
Popova Nevena, Shishkov Georgi, Koprinkova-Hristova Petia, Alexiev Kiril   +3 more
doaj   +1 more source

ImpaCT2: the impact of information and communication technologies on pupil learning and attainment [PDF]

, 2002
The report explores the impact of networked technologies on patterns of use of ICT in English, Mathematics and Science at Key Stages 2, 3 and 4 and the relative gain for high ICT users versus low ICT users in each of these subjects.
Comber, Chris, Fisher, Tony, Harrison, Colin, Haw, Kaye, Lewin, Cathy, Lunzer, Eric, Mavers, Diane, McFarlane, Angela, Scrimshaw, Peter, Somekh, Bridget, Watling, Rob   +10 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

LightIN: a versatile silicon-integrated photonic field programmable gate array with an intelligent configuration framework for next-generation AI clusters

Light: Science & Applications
Artificial Intelligence models pose serious challenges to intensive computing and high-bandwidth communication for conventional electronic circuit-based computing clusters.
Ying Zhu, Yifan Liu, Xinyu Yang, Kailai Liu, Xin Hua, Ming Luo, Jia Liu, Siyao Chang, Jie Yan, Shengxiang Zhang, Miao Wu, Zhicheng Wang, Hongguang Zhang, Dong Wang, Daigao Chen, Xi Xiao, Shaohua Yu   +16 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Information and communication technologies in education [PDF]

, 2014
Рассматриваются перспективы использования информационно-коммуникационных технологий в образовательной деятельности ВУЗов. Анализируются возможности современных электронных систем, а также результаты их внедрения в учебный процесс.The possibility of ...
Balashov, S., Bishevksy, V., Verner, I., Балашов, Сергей Васильевич, Балашов, Сергій Васильович, Бышевский, В. И., Вернер, Илья Владимирович, Вернер, Ілля Володимирович   +7 more
core   +1 more source