Results 41 to 50 of about 534,779 (294)

Adding critical sensibilities to domestic communication technologies [PDF]

, 2009
This paper presents suggestions for a more pragmatic approach to the design of emerging and future domestic communication technologies, particularly technologies destined for the home that maybe deemed ‘ubiquitous’. This is achieved through two critical
Bonner, John V H, Bonner, John V.H.
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Reduced Multiplicative (BURA-MR) and Additive (BURA-AR) Best Uniform Rational Approximation Methods and Algorithms for Fractional Elliptic Equations

Fractal and Fractional, 2021
Numerical methods for spectral space-fractional elliptic equations are studied. The boundary value problem is defined in a bounded domain of general geometry, Ω⊂Rd, d∈{1,2,3}. Assuming that the finite difference method (FDM) or the finite element method (
Stanislav Harizanov, Nikola Kosturski, Ivan Lirkov, Svetozar Margenov, Yavor Vutov   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Introducing Information Communication Technologies into Humanitarian Programming

, 2018
Digital technologies are radically transforming the ways in which aid agencies can interact with the communities with whom they work. Oxfam believes that information communication technologies (ICTs) offer a huge opportunity to amplify and ...
Kondakhchyan, Anna, Eldon, Laura
core   +1 more source

Profilbereich "Information & Communication Technology"

, 2020
Published by RWTH ...
Kinny, Renate, Hamacher, Angelika
openaire   +2 more sources

Information and communication in a networked infosphere: a review of concepts and application in social branding [PDF]

, 2015
This paper aims at providing a contribution to the comprehensive review of the impact of information and communication, and their supporting technologies, in the current transformation of human life in the infosphere.
Fernando Manuel Santos Ramos, Chaves Mealha, Óscar Emanuel, Santos Ramos, Fernando Manuel, Óscar Emanuel Chaves Mealha, Lelis, Catarina, Catarina Franco Lélis, Franco Lélis, Catarina, Ramos, Fernando, Mealha, Oscar   +8 more
core   +1 more source