Results 61 to 70 of about 534,779 (294)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Information and communication technologies and geographic concentration of manufacturing industries: Evidence from China [PDF]

open access: yes
Using the 2004 China economic census database, this paper examines the impact of information and communication technologies (ICT) on the geographic concentration of manufacturing industries, controlling for other determinants of industrial agglomeration.
Fu, Shihe, Hong, Junjie
core   +2 more sources

Towards Robust Evaluation of Aesthetic and Photographic Quality Metrics: Insights from a Comprehensive Dataset

open access: yesComplexity
In recent years, the development of metrics to evaluate image aesthetics and photographic quality has proliferated. However, validating these metrics presents challenges due to the inherently subjective nature of aesthetics and photographic quality ...
Iria Santos   +5 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

open access: yesFEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura   +19 more
wiley   +1 more source

An integrated approach to forecasting software system quality using bayesian correction, multi-criteria optimization, and meta-learning

open access: yesРадіоелектронні і комп'ютерні системи
The aim of this study is to improve modern methods for forecasting the quantitative characteristics of software system quality to enhance reliability, efficiency, and adaptability in dynamic IT environments.
Anton Shantyr   +4 more
doaj   +1 more source

Information and Communication technologies as agricultural extension tools [PDF]

open access: yes
Knowledge and innovation society are becoming priorities to the welfare and quality of life of the rural population. This is based substantially on scientific and technological progress.
Afroditi Papadaki-Klavdianou   +2 more
core  

Effect of terahertz irradiation on DNA damage repair in living cells

open access: yesFEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno   +3 more
wiley   +1 more source

Experimental Validation of Human-Readable Coded Targets for Cross-Platform Photogrammetry and 3D Laser Scanning [PDF]

open access: yesThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Coded targets are widely used in close-range photogrammetry and 3D laser scanning for automated referencing and registration. However, most fiducial systems are optimized for specific software environments, limiting interoperability across processing ...
M. Raykovska   +9 more
doaj   +1 more source

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