Results 41 to 50 of about 616,726 (261)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Design and Information Architectures for an Unmanned Aerial Vehicle Cooperative Formation Tracking Controller

IEEE Access, 2018
This paper addresses a well-documented open problem on the tracking target of the multiple unmanned aerial vehicles (UAVs) subject to the inconsistent of attitude and position in the process of flight.
Jialong Zhang, Jianguo Yan, Pu Zhang, Xiangjie Kong   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Perencanaan Arsitektur Enterprise Menggunakan TOGAF ADM (Studi Kasus: Kantor Desa Lembang)

Journal of Information Systems and Informatics, 2021
The Lembang Village Office is a government institution that operates at the Village level in the Bengkayang Regency area. The Lembang Village Government has not implemented an Information System in carrying out its duties, this can be seen from the ...
Desy Angeline, Charitas Fibriani
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Information decomposition and the informational architecture of the brain

Trends in Cognitive Sciences
To explain how the brain orchestrates information-processing for cognition, we must understand information itself. Importantly, information is not a monolithic entity. Information decomposition techniques provide a way to split information into its constituent elements: unique, redundant, and synergistic information.
Andrea I. Luppi, Fernando E. Rosas, Pedro A.M. Mediano, David K. Menon, Emmanuel A. Stamatakis   +4 more
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

On a model of enterprise architecture for public institutions in Romania

Responsibility and Sustainability, 2013
This paper presents a possibility to conceive the conceptual design of a Romanian public institution using a methodology known as the “Enterprise Architecture”.
Cristian Bologa, José Luis Vázquez, Gheorghe Faur, Paul Bresfelean, Nicolae Ghisoiu   +4 more
doaj  

Information Architecture Strategies in the Classroom: How Do Increasingly Complex Digital Ecosystems in Higher Education Shape the Contours of Instructor-Student Communication?

Teaching & Learning Inquiry: The ISSOTL Journal
The proliferation of digital software is an increasingly accepted part of everyday life in higher education in the United States. While this software affords some opportunities, it can create confusing experiences for students as well.
Michael Lahey
doaj   +1 more source