Results 41 to 50 of about 2,020,327 (242)

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Efficient deep CNNs for cross-modal automated computer vision under time and space constraints [PDF]

open access: yes, 2019
We present an automated computer vision architecture to handle video and image data using the same backbone networks. We show empirical results that lead us to adopt MOBILENETV2 as this backbone architecture.
Amirian, Mohammadreza   +4 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Information architecture for a federated health record server [PDF]

open access: yes, 2002
This paper describes the information models that have been used to implement a federated health record server and to deploy it in a live clinical setting.
Austin, T   +5 more
core  

Locust-inspired vision system on chip architecture for collision detection in automotive applications [PDF]

open access: yes, 2006
This paper describes a programmable digital computing architecture dedicated to process information in accordance to the organization and operating principles of the four-layer neuron structure encountered at the visual system of Locusts.
Carranza González, Luis   +6 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

An Architecture for Information Commerce Systems [PDF]

open access: yes, 2001
The increasing use of the Internet in business and commerce has created a number of new business opportunities and the need for supporting models and platforms.
Di Nitto, Elisabetta   +5 more
core   +3 more sources

PROPYLA: Privacy Preserving Long-Term Secure Storage

open access: yes, 2018
An increasing amount of sensitive information today is stored electronically and a substantial part of this information (e.g., health records, tax data, legal documents) must be retained over long time periods (e.g., several decades or even centuries ...
Bayer Dave   +9 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

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