Results 61 to 70 of about 13,106,885 (303)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
IEEE Access, 2018 This paper addresses a well-documented open problem on the tracking target of the multiple unmanned aerial vehicles (UAVs) subject to the inconsistent of attitude and position in the process of flight.
Jialong Zhang +3 more
doaj +1 more source
Perencanaan Arsitektur Enterprise Menggunakan TOGAF ADM (Studi Kasus: Kantor Desa Lembang)
Journal of Information Systems and Informatics, 2021 The Lembang Village Office is a government institution that operates at the Village level in the Bengkayang Regency area. The Lembang Village Government has not implemented an Information System in carrying out its duties, this can be seen from the ...
Desy Angeline, Charitas Fibriani
doaj +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Architectural informality [PDF]
, 2021 Πρόθεση της διατριβής είναι να τονίσει και να διερευνήσει πλευρές της αντίληψης του αστικού χώρου και της αρχιτεκτονικής που διαφεύγουν της συνειδητής λογικής θεώρησης, προσεγγίζοντας τις μέσω του φανταστικής αφήγησης – να τεκμηριώσει και να αναλύσει τον αστικό κύκλο ζωής των τάσεων εκείνων που ο ιστορικός της αρχιτεκτονικής Sigfried Giedion ταξινομεί ...
openaire +1 more source