Results 61 to 70 of about 31,327,276 (340)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
MIA: Multimodal Information Architecture
, 2018 Presentation for the 2018 International Conference on Knowledge Management. This presentation presents ways toward a Multimodal Information Architecture with possible strategies for designing models of representation for meaning ...
Gottschalg-Duque, Cláudio +1 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
A Theory of Information Trilogy: Digital Ecosystem Information Exchange Architecture [PDF]
, 2021 Information sharing is a critical component of a distributed and multi‐actor digital ecosystem (DE). DE actors, individuals and organisations, require seamless, effective, efficient, and secure architecture for exchanging information.
Gill, AQ, Asif Qumer Gill
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Graph-based implicit knowledge discovery from architecture change logs [PDF]
, 2012 Service architectures continuously evolve as a consequence of frequent business and technical change cycles. Architecture change log data represents a source of evolution-centric information in terms of intent, scope and operationalisation to ...
Pooyan Jamshidi (5276344) +12 more
core +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
IEEE Access, 2018 This paper addresses a well-documented open problem on the tracking target of the multiple unmanned aerial vehicles (UAVs) subject to the inconsistent of attitude and position in the process of flight.
Jialong Zhang +3 more
doaj +1 more source
Art, Architecture, and Design Information Competencies: Graphic Design, Interior Design, Photography, Urban and Regional Planning [PDF]
, 2019 These ARLIS/NA reports on student information competencies reevaluates and broadens the Information Competencies for Students in Design Disciplines (2006, updated 2007).
Stephanie Beene +7 more
core +1 more source