Results 71 to 80 of about 31,327,276 (340)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
DataHousing tokenisation usually reaches the public as a story about technological innovation. The account offered here starts elsewhere, from its legal form and its data architecture, and situates the phenomenon among the infrastructures of the smart city ...
José Francisco Vergara-Perucich
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A Framework for Information Architecture for Business Networks [PDF]
The concept of Information Architecture (IA) has been independently explored by researchers and practitioners in Information Engineering, Information Systems (ISmanagement, information visualisation and Web site design.
Bobeva, Milena
core +5 more sources
BLAST+: architecture and applications
BMC Bioinformatics, 2009 BackgroundSequence similarity searching is a very important bioinformatics task. While Basic Local Alignment Search Tool (BLAST) outperforms exact methods through its use of heuristics, the speed of the current BLAST software is suboptimal for very long ...
C. Camacho +6 more
semanticscholar +1 more source
, 2018 These ARLIS/NA reports on student information competencies reevaluates and broadens the Information Competencies for Students in Design Disciplines (2006, updated 2007).
James Sobczak +8 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
On a model of enterprise architecture for public institutions in Romania
Responsibility and Sustainability, 2013 This paper presents a possibility to conceive the conceptual design of a Romanian public institution using a methodology known as the “Enterprise Architecture”.
Cristian Bologa +4 more
doaj
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source