Results 71 to 80 of about 616,726 (261)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Effects of Information Architecture on the Effectiveness and User Experience of Web-Based Patient Education in Middle-Aged and Older Adults: Online Randomized Experiment. [PDF]

J Med Internet Res, 2021
Dekkers T, Melles M, Vehmeijer SBW, de Ridder H.   +3 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Metadados de negócio: representação da informação dos processos de trabalho

Transinformação, 2019
Resumo Metadados são considerados elementos fundamentais na Ciência da Informação e suas características, aplicações e tipologias vêm sendo bastante estudados pelos pesquisadores da área, principalmente a partir dos anos 2000.
Mariana Baptista BRANDT, Silvana Aparecida Borsetti Gregorio VIDOTTI   +1 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Developing an Architectural Model for Social Health Networks and the Possible Risks of its Implementation in Shariati Hospital

پیاورد سلامت, 2018
Background and Aim: The emergence of Web interactive technologies has enabled interactive social networking services. The purpose of this research is to choose a model and present an architectural design for the social network of health at Shariati ...
Atefeh Sadat Haghighat Hoseini, Hossein Bobarshad, Fatemeh Saghafi, Iman Noroozi   +3 more
doaj  

An overview of scientific productions on information architecture in the context of Information Science

Biblios
Objective. Provide an overview of the scientific production on Information Architecture in the context of Information Science. Method. It is characterized as an exploratory and qualitative-quantitative study which used bibliometric techniques and ...
Elanna Beatriz Americo Ferreira, Sandra De Albuquerque Siebra   +1 more
doaj   +1 more source

Urban planning: integrating smart applications to promote community engagement

Heliyon, 2019
Through the last decades, the development of technology was rapid. As a result, changes in a series of sectors of human life have been observed. One of these sectors is spatial planning, where new applications contribute towards its skillful application.
Vassiliki Delitheou, Efthimios Bakogiannis, Charalampos Kyriakidis   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source