Results 81 to 90 of about 2,020,327 (242)

Scholarly information architecture, 1989 - 2015

Data Science Journal, 2006
If we were to start from scratch today to design a quality-controlled archive and distribution system for scientific and technical information, it could take a very different form from what has evolved in the past decade from pre-existing print ...
P Ginsparg
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

INFORMATION ARCHITECTURE AND JOURNALISM CONVERGENCE:

Ergodesign & HCI, 2016
Information architecture; Digital journalism; Taxonomy, Ergodesign. This work aims to contribute, through a case study of a Brazilian newspaper, for the development of scientific literature related to online newspaper design.
Diana A. B. dos Santos, Luiz Agner
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Architecture alignment in a large government organization : a case study [PDF]

, 2004
In this paper we view IT architecture as the structures present in the entire information technology support used by an organization. Research into IT architecture either is of a strategic nature, yielding no operational guidelines for the practicing IT ...
Blanken, H.M., Eck, P.A.T. van, Wieringa, R.J.   +2 more
core   +3 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Information Architecture / Enformasyon Mimarisi [PDF]

Bilgi Dünyası, 2004
For some time now, the pundits have been declaiming that “Information is the fourth resource”, and that to ignore that fact will inevitably lead to organisational catastrophe.
Alan Gilchrist
doaj  

An Integrated Enterprise Architecture Framework for Business-IT Alignment [PDF]

, 2006
When different businesses want to integrate part of their processes and IT, they need to relate their enterprise architecture frameworks. An enterprise architecture framework (EAF) is a conceptual framework for describing the architecture of a business ...
Wieringa, Roel, Zarvic, Novica
core   +1 more source