Results 81 to 90 of about 13,106,885 (303)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Infovis mechanisms in information architecture
Toruńskie Studia Bibliologiczne, 2014 Modern methods of information visualization (Infovis) utilize visual perception. Visualization techniques allow to present data at different organization levels in order to facilitate human understanding of complex spatial or visual data relationships ...
Veslava Osińska
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
On a model of enterprise architecture for public institutions in Romania
Responsibility and Sustainability, 2013 This paper presents a possibility to conceive the conceptual design of a Romanian public institution using a methodology known as the “Enterprise Architecture”.
Cristian Bologa +4 more
doaj
Scholarly information architecture, 1989 - 2015
Data Science Journal, 2006 If we were to start from scratch today to design a quality-controlled archive and distribution system for scientific and technical information, it could take a very different form from what has evolved in the past decade from pre-existing print ...
P Ginsparg
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
INFORMATION ARCHITECTURE AND JOURNALISM CONVERGENCE:
Ergodesign & HCI, 2016 Information architecture; Digital journalism; Taxonomy, Ergodesign. This work aims to contribute, through a case study of a Brazilian newspaper, for the development of scientific literature related to online newspaper design.
Diana A. B. dos Santos, Luiz Agner
doaj +1 more source
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
Material-Inherent Noise Sources in Quantum Information Architecture. [PDF]
Materials (Basel), 2023 Yang H, Kim NY.
europepmc +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source