Results 91 to 100 of about 13,106,885 (303)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Architecture design approach for IoT-based farm management information systems

open access: yesPrecision Agriculture, 2018
Smart farming adopts advanced technology and the corresponding principles to increase the amount of production and economic returns, often also with the goal to reduce the impact on the environment.
Ö. Köksal, B. Tekinerdogan
semanticscholar   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Information Architecture / Enformasyon Mimarisi [PDF]

open access: yesBilgi Dünyası, 2004
For some time now, the pundits have been declaiming that “Information is the fourth resource”, and that to ignore that fact will inevitably lead to organisational catastrophe.
Alan Gilchrist
doaj  

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Metadados de negócio: representação da informação dos processos de trabalho

open access: yesTransinformação, 2019
Resumo Metadados são considerados elementos fundamentais na Ciência da Informação e suas características, aplicações e tipologias vêm sendo bastante estudados pelos pesquisadores da área, principalmente a partir dos anos 2000.
Mariana Baptista BRANDT   +1 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Developing an Architectural Model for Social Health Networks and the Possible Risks of its Implementation in Shariati Hospital

open access: yesپیاورد سلامت, 2018
Background and Aim: The emergence of Web interactive technologies has enabled interactive social networking services. The purpose of this research is to choose a model and present an architectural design for the social network of health at Shariati ...
Atefeh Sadat Haghighat Hoseini   +3 more
doaj  

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