Results 181 to 190 of about 1,859,644 (362)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Report of the California Military Base Reuse Task Force to Governor Pete Wilson : a strategic response to base reuse opportunities

open access: yes, 1994
The California Military Base Reuse Task Force was asked to identify the problems that have inhibited the successful conversion of closing California military bases and to make recommendations to you for overcoming these barriers.
California Military Base Reuse Task Force
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

An Information-Based Approach to Punctuation.

open access: yes, 2016
Punctuation marks have special importance in bringing out the meaning of a text. Geoffrey Nunberg's 1990 monograph bridged the gap between descriptive treatments of punctuation and perspective accounts, by spelling out the features of a text-grammar for the orthographic sentence.
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Collaborative real-time traffic information generation and sharing framework for the intelligent transportation system

open access: yes, 2010
[[abstract]]Real-time traffic information collection and data fusion is one of the most important tasks in the advanced traffic management system (ATMS), and sharing traffic information to users is an essential part of the advance traveler information ...
Lee, WH (Lee, Wei-Hsun); Tseng, SS (Tseng, Shian-Shyong); Shieh, WY (Shieh, Wern-Yarng)
core  

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