Results 141 to 150 of about 2,161,269 (246)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Online Information Behavior Regarding COVID-19 Vaccination and Its Association With Vaccination Behavior Based on Cluster Analysis of User Groups: Cross-Sectional Study. [PDF]

JMIR Infodemiology
Liebner L, Babitsch B, Schmidt L.
europepmc   +1 more source

Effect of Patient-Physician Relationship on Withholding Information Behavior: Analysis of Health Information National Trends Survey (2011-2018) Data. [PDF]

J Med Internet Res, 2020
Yang X, Parton J, Lewis D, Yang N, Hudnall M.   +4 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Health Information Behavior in Parents of Children With Congenital Heart Disease in China: Qualitative Study Through the Lens of Chinese Culture. [PDF]

J Med Internet Res
Yang J, Ma F, Wang Y, Yang X, Zhou M, Zhang Y, Zhang Y, YangLan R, Li Q.   +8 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Data Creation Practices of Archaeologists in the Field

Informaatiotutkimus
Michael Olsson
doaj   +1 more source

Exploring motivations, information behavior, perceptions, and intentions among dietary supplement users: a cross-sectional survey study in Germany. [PDF]

Front Nutr
Janzik R, Geppert J, Müller P, Notz I, Obstfeld H, Roth B, Volpers AM, Böl GF.   +7 more
europepmc   +1 more source

Exploring the impact of emergency risk information on construction workers' emergency information behavior: insights from confirmatory and exploratory PLS-SEM analyses. [PDF]

Front Public Health
Liu H, Zhang R, Gao X, Jing R, Zhang Z, Miao X.   +5 more
europepmc   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source