A process-based approach to exploring the information behavior of informal caregivers of people living with dementia. [PDF]
Int J Med Inform, 2021 Rutkowski RA +5 more
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
[Health information behavior of 65+: reaching older target groups]. [PDF]
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 2021 Stehr P, Weber W, Rossmann C.
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Understanding patrons' Micro-Level Information Seeking (MLIS) in Information Retrieval Situations.
, 2010 [[abstract]]Elicitation is a communicative act to request information during a dialogue, which reflects the questioner's problems at hand, perplexity, interests, or perhaps internal concerns, either voluntarily or unintentionally.
Wu, Mei-Mei, 吳美美
core
From information seeking to information avoidance: Understanding the health information behavior during a global health crisis. [PDF]
Inf Process Manag, 2021 Soroya SH +4 more
europepmc +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
, 1997 application/pdf; Cover title.; "February 25, 1997."; "The Chief Information Architect (CIA), working with the Kansas Information Resources Council (KIRC)..."--Abstract, page ...
Kansas. Office of the Chief Information Architect.
core