Results 241 to 250 of about 689,793 (290)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

The Evolution of Masturbation in Birds. [PDF]

Ecol Evol
Heys C, Arbuckle K, Brindle M, Price TAR.   +3 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The "Are You OK?" Paradox: A Scoping Review of Nocebo and Negative Suggestion in Healthcare Communication. [PDF]

Dent J (Basel)
O'Brien OK, Donnell CC.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Behaviour change support education in chronic disease: An international focus group study with undergraduate students and academic educators in nursing, pharmacy and sport science disciplines. [PDF]

PLoS One
Félix IB, Nascimento C, Pereira P, Braam K, Cadogan C, Strawbridge J, Budler LC, Gosak L, Pimenta N, Guerreiro MP.   +9 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Intervention development to reduce sedentary behaviour among adults: a qualitative investigation using the Behaviour Change Wheel. [PDF]

Int J Behav Nutr Phys Act
Harsanyi H, Slot N, Parkinson R, Morielli AR, Jeyapalan A, Holmes E, Flynn S, Campbell T, Quan H, Zeng Y, Yang J, Singh S, Vena J, Biddle S, Friedenreich CM, Yang L.   +15 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Facing Dementia in Primary Care: Applying the COM-B Model to Develop a Complex Intervention to Improve Dementia Diagnosis Rates in General Practice. [PDF]

Int J Environ Res Public Health
Gibson C, Yates M, Pond CD, Daly S, Jebramek J, Phillipson L, Laver K, Gresham M, Tan E, Brodaty H, Swann J, Ferdousi S, Low LF.   +12 more
europepmc   +1 more source