, 1983 International Association of Aquatic and Marine Science Libraries and Information Centers
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Design and Key Technology of Gardening Information Management System Based on Data Center
, 2010 Xi-Guang Wang, Wei-Hua Lin, Wen Zeng
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Operationalizing Access for Chimeric Antigen Receptor T cell Therapies: A Cross-functional Perspective. [PDF]
Mayo Clin Proc Innov Qual OutcomesSingh S +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
THE MATHEMATICAL MODELS OF SEARCHING DATA IN THE CENTERS OF INFORMATION RESOURCES
, 2016 Bahodir Boltayevich Muminov .
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Combining forces in dual certified centers of geriatric trauma/joint replacement according to the German trauma society (DGU)/endocert improves mobility and quality of life in elderly patients with femoral neck fractures: an analysis from the registry for geriatric trauma (ATR-DGU). [PDF]
Eur J Trauma Emerg SurgLampert C +13 more
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, 1985 International Association of Aquatic and Marine Science Libraries and Information Centers
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