Results 271 to 280 of about 15,718,666 (366)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Building medical toxicology capacity in Africa: a review and strategic perspective on the need for fellowship training programs. [PDF]

Int J Emerg Med
Kassa BD.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Decentralizing care for cutaneous leishmaniasis and other skin diseases to primary health facilities in Southern Ethiopia: What are the needs? [PDF]

BMC Infect Dis
Tadesse D, Henten SV, Batire S, Woge MT, Degaga TS, Merdekios B, Abrams S, Hailu A, Geertruyden JV, Griensven JV, Pareyn M.   +10 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

A Lightweight Privacy-Enhanced Federated Clustering Algorithm for Edge Computing. [PDF]

Sensors (Basel)
Wang J, Chen X, Cheng X, Zhang J, Yu T, Qian K.   +5 more
europepmc   +1 more source

Bridging the Gap: Identifying and Overcoming Barriers to CAR-T Access Through Streamlined and Standardized Pathways. [PDF]

Mayo Clin Proc Innov Qual Outcomes
Uttam Chandani K, Khera N.
europepmc   +1 more source

Development of a Web and Mobile-Based MSME Information System Using a User-Centered Design Approach

Dimas Anugrah Putra Alfarizqy, Ahmad Tri Hidayat   +1 more
openalex   +2 more sources

High-Purity Single Photon Extraction from Diamond Nitrogen-Vacancy Centers in Low-Numerical-Aperture Optical Systems via Defect-Selective Metalens Printing. [PDF]

Small
Jeon M, Kim M, Park NR, Choi Y, Lee J, Kim C, Han SW, Kang DD, Jeon SW, Kim MK.   +9 more
europepmc   +1 more source