Results 31 to 40 of about 23,833,705 (251)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A Survey of Solving Approaches for Multiple Objective Flexible Job Shop Scheduling Problems

Cybernetics and Information Technologies, 2015
Many real life scheduling problems can be formulated as Flexible Job Shop Scheduling Problems (FJSSPs) which simultaneously optimize several conflicting criteria. A typical feature of such problems is their high computational complexity.
Genova Krasimira, Kirilov Leoneed, Guliashki Vassil   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Adding critical sensibilities to domestic communication technologies [PDF]

, 2009
This paper presents suggestions for a more pragmatic approach to the design of emerging and future domestic communication technologies, particularly technologies destined for the home that maybe deemed ‘ubiquitous’. This is achieved through two critical
Bonner, John V H, Bonner, John V.H.
core   +1 more source

Autonomic Properties in Traffic Control

Cybernetics and Information Technologies, 2013
The operation of a complex system like a transportation network is considered with respect to the opportunities to identify the application of autonomic properties. The autonomic features of self-properties are analyzed.
Stoilova Krasimira, Stoilov Todor, Nikolov Konstantin   +2 more
doaj   +1 more source

A Near Real-Time Method for Forest Change Detection Based on a Structural Time Series Model and the Kalman Filter

Remote Sensing, 2020
The increasing availability of dense time series of earth observation data has incited a growing interest in time series analysis for vegetation monitoring and change detection.
Martin Puhm, Janik Deutscher, Manuela Hirschmugl, Andreas Wimmer, Ursula Schmitt, Mathias Schardt   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

MODELING OF BUSINESS PROCESSES FOR MANAGING INTEGRATIVE DIGITAL DEVELOPMENT OF ENTERPRISES [PDF]

Academy Review
It has been proven that the development of information and communication services enterprises is of strategic importance for the complementary growth of all sectors of the Ukrainian economy and serves as a platform for boosting and advancing proactive ...
Оlena V. Vynogradova, Svitlana V. Lehominova, Aliona Yu. Goloborodko, Tetiana I. Nosova   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source