Results 151 to 160 of about 2,712,310 (266)

Information-Content-Informed Kendall-Tau Correlation Methodology: Interpreting Missing Values in Metabolomics as Potentially Useful Information. [PDF]

Metabolites
Flight RM, Bhatt PS, Moseley HNB.
europepmc   +1 more source

A smartphone-based self-care application for patients with urinary tract stones: identification of information content and functional capabilities. [PDF]

BMC Urol, 2022
Shahmoradi L, Azizpour A, Bejani M, Shadpour P, Rezayi S, Farzi J, Amanollahi A.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Multimodal Integration Enhances Tissue Image Information Content: A Deep Feature Perspective. [PDF]

Bioengineering (Basel)
Darzi F, Bocklitz T.
europepmc   +1 more source

INFORMATION CONTENT OF HIGH-ORDER ASSOCIATIONS OF THE HUMAN GUT MICROBIOTA NETWORK. [PDF]

Ann Appl Stat, 2021
Viles WD, Madan JC, Li H, Karagas MR, Hoen AG.   +4 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

MSCI: an open-source Python package for information content assessment of peptide fragmentation spectra. [PDF]

Bioinform Adv
Elhamraoui Z, Borràs E, Wilhelm M, Sabidó E.   +3 more
europepmc   +1 more source

A data value metric for quantifying information content and utility. [PDF]

J Big Data, 2021
Noshad M, Choi J, Sun Y, Hero A, Dinov ID.   +4 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Supporters and Skeptics: LLM-based Analysis of Engagement with Mental Health (Mis)Information Content on Video-sharing Platforms. [PDF]

Proc Int AAAI Conf Weblogs Soc Media
Nguyen VC, Jain M, Chauhan A, Soled HJ, Lesmes SA, Li Z, Birnbaum ML, Tang SX, Kumar S, De Choudhury M.   +9 more
europepmc   +1 more source