Results 111 to 120 of about 19,416,832 (324)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

MARKETING RESEARCH REGARDING FACULTY-CHOISE CRITERIA AND INFORMATION SOURCES UTILISED [PDF]

Today, marketing is essential to any educational institution of higher education, so much as it is imperative that the needs of potential candidates to be identified and satisfied in a manner which will generate long-term effects (post-graduation), may ...
BACILA Mihai-Florin, POP Marius Dorel, TÎRCA Alexandra-Maria   +2 more
core  

Information criteria for latent factor models: a study on factor pervasiveness and adaptivity. [PDF]

J Econom, 2023
Guo X, Chen Y, Tang CY.
europepmc   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

An integrated modelling framework for evaluating the synergistic impacts of low-carbon transitions and air pollution controls on air quality and health in Guangzhou, China

Advances in Climate Change Research
Climate policies that target carbon emissions can induce co-benefits for air quality. Previous urban studies have typically focused on either carbon reduction or air pollution control independently, but few have examined their combined effects on ...
Yun Shu, Yang Li, Yazhen Wu, Xiang-Zhao Feng, Sha-Sha Xu, Ya-Li Wang, Tong Ma, Jian-Hua Chen, Jian Gao, Shaohui Zhang, Ji-Zhang Huang   +10 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

On the Choice of the Item Response Model for Scaling PISA Data: Model Selection Based on Information Criteria and Quantifying Model Uncertainty. [PDF]

Entropy (Basel), 2022
Robitzsch A.
europepmc   +1 more source

ASYMPTOTIC CUMULANTS OF SOME INFORMATION CRITERIA

Journal of the Japanese Society of Computational Statistics, 2016
Summary: Asymptotic cumulants of the Akaike and Takeuchi information criteria are given under possible model misspecification up to the fourth order with the higher-order asymptotic variances, where two versions of the latter information criterion are defined using observed and estimated expected information matrices.
openaire   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source