Results 91 to 100 of about 749,941 (338)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Geometric information flows and G. Perelman entropy for relativistic classical and quantum mechanical systems [PDF]

, 2020
Sergiu I. Vacaru
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Chaos for Liouville probability densities

, 1995
Using the method of symbolic dynamics, we show that a large class of classical chaotic maps exhibit exponential hypersensitivity to perturbation, i.e., a rapid increase with time of the information needed to describe the perturbed time evolution of the ...
A. J. Lichtenberg, A. N. Kolmogorov, A. N. Kolmogorov, A. Peres, B. O. Koopman, C. E. Shannon, C. E. Shannon, C. E. Shannon, C. M. Caves, C. M. Caves, C. M. Caves, Carlton M. Caves, D. S. Ornstein, D. Welsh, E. Borel, E. Borel, E. T. Jaynes, E. T. Jaynes, E. T. Jaynes, G. J. Chaitin, H. Spohn, J. Ford, J. P. Crutchfield, M. V. Berry, R. Landauer, R. Landauer, R. Schack, R. Schack, R. Schack, Rüdiger Schack, V. I. Arnold, V. M. Alekseev, W. H. Zurek, W. H. Zurek   +33 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Augmentation of nucleon-nucleus scattering by information entropy

, 2011
Quantum information entropy is calculated from the nucleon nucleus forward scattering amplitudes. Using a representative set of nuclei, from $^4$He to $^{208}$Pb, and energies, $T_{lab} < 1$\,[GeV], we establish a linear dependence of quantum information
Amos K., Bengtsson I., Cover T. M., Feshbach H., H. V. VON GERAMB, Nielsen M. A., S. E. MASSEN, V. P. PSONIS   +7 more
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Information Entropy-Based Attribute Reduction for Incomplete Set-Valued Data [PDF]

, 2021
Yuanxia Zhang, Chen Zuo-zan
openalex   +1 more source

On some interrelations of generalized $q$-entropies and a generalized Fisher information, including a Cram\'er-Rao inequality [PDF]

, 2013
In this communication, we describe some interrelations between generalized $q$-entropies and a generalized version of Fisher information. In information theory, the de Bruijn identity links the Fisher information and the derivative of the entropy.
Bercher, Jean-François
core   +3 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source