Results 161 to 170 of about 71,768 (198)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

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Evaluating Information Assurance Strategies*

Decision Support Systems, 2005
The information revolution has provided new and improved capabilities to rapidly disseminate and employ information in decision-making. Enhancing and enabling for today's modern industry, these capabilities are critical to our national infrastructures.
J. Todd Hamill, Richard F. Deckro, Jack M. Kloeber Jr.   +2 more
openaire   +1 more source

Evaluation of evaluation in information retrieval

Proceedings of the 18th annual international ACM SIGIR conference on Research and development in information retrieval - SIGIR '95, 1995
Evaluation is a major force in research, development and applications related to information retrieval (IR). This paper is a critical and historical analysis of evaluations of IR systems and processes. Strengths and shortcomings of evaluation efforts and approaches are discussed. together with major challenges and questions.
openaire   +1 more source

Evaluating information visualisations

Proceedings of the 2006 AVI workshop on BEyond time and errors: novel evaluation methods for information visualization, 2006
As more experience is being gained with the evaluation of information visualisation interfaces, weaknesses in current evaluation practice are coming to the fore.This position paper presents an overview of currently used evaluation methods, followed by a discussion of my experiences and lessons learned from a series of studies comparing hierarchy ...
openaire   +2 more sources

Information independent evaluation of information systems

Information & Management, 1983
Abstract Information systems are characterized and their desirable features are identified. Information independence is proposed as a major architectural characteristic underlying many desirable features. Two types of information independence are identified and an approach to quantifying the degree of independence is introduced.
openaire   +2 more sources

Evaluation of criteria for information retrieval

Proceedings IEEE/WIC International Conference on Web Intelligence (WI 2003), 2004
AbstractWe investigate van Rijsbergen'sF‐measure, the break‐even point, and 11‐point averaged precision, all of which can be translated into one‐dimensional scalar quantities from the precision and the recall. These investigations can be done by comparing to the tetrachoric (four‐fold) correlation coefficient and phi (four‐fold point) coefficient ...
openaire   +2 more sources

Evaluation in Information Visualization: Heuristic Evaluation

2012 16th International Conference on Information Visualisation, 2012
This paper presents a review of heuristic evaluation and recommendations for how to apply the method for information visualization evaluation. Heuristic evaluation is a widely known and popular method within the area of human-computer interaction and the information visualization community now also recognizes its usefulness. However, in this area it is
openaire   +2 more sources

Evaluation in Information Retrieval

2000
In this talk I summarize the components of a traditional laboratory-style evaluation experiment in information retrieval (as exemplified by TREC), and discusses some of the issues around this form of experiment. Some kinds of research questions fit very well into this framework; others much less easily. The major area of difficulty for the framework is
openaire   +2 more sources

Information bazaar

Proceedings of the 5th ACM workshop on HotPlanet, 2013
The rise in the number of smart devices has created a large ecosystem centred on users? personal information and online activities. Numerous smartphone applications and social networking sites harvest and catalogue users' personal information, enabling brokers such as Google and Facebook to provide a platform for advertisers to use this information for
Bernadette Kamleitner, Stephan Dickert, Marjan Falahrastegar, Hamed Haddadi 0001   +3 more
openaire   +1 more source