Results 111 to 120 of about 3,082,391 (312)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Deep Learning for Multi-Class Identification From Domestic Violence Online Posts
IEEE Access, 2019 Domestic violence (DV) is not only a major health and welfare issue but also a violation of human rights. In recent years, domestic violence crisis support (DVCS) groups active on social media have proven indispensable in the support services provided to
Sudha Subramani +5 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Modeling concepts and their relationships for corpus-based query auto-completion
Open Computer Science, 2019 Query auto-completion helps users to formulate their information needs by providing suggestion lists at every typed key. This task is commonly addressed by exploiting query logs and the approaches proposed in the literature fit well in web scale ...
Rossiello Gaetano +3 more
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Graphene: Semantically-Linked Propositions in Open Information Extraction
, 2018 We present an Open Information Extraction (IE) approach that uses a two-layered transformation stage consisting of a clausal disembedding layer and a phrasal disembedding layer, together with rhetorical relation identification.
Cetto, Matthias +3 more
core
An Information Bottleneck Approach for Controlling Conciseness in\n Rationale Extraction [PDF]
, 2020 Bhargavi Paranjape +4 more
openalex +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Effective Signal Extraction Algorithm for Cerebral Blood Oxygen Based on Dual Detectors
SensorsFunctional near-infrared spectroscopy (fNIRS) can dynamically respond to the relevant state of brain activity based on the hemodynamic information of brain tissue. The cerebral cortex and gray matter are the main regions reflecting brain activity.
Zhiming Xing +3 more
doaj +1 more source