Results 71 to 80 of about 1,334,537 (258)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

myDIG: Personalized Illicit Domain-Specific Knowledge Discovery with No Programming

Future Internet, 2019
With advances in machine learning, knowledge discovery systems have become very complicated to set up, requiring extensive tuning and programming effort.
Mayank Kejriwal, Pedro Szekely
doaj   +1 more source

Missing Procedural Texts Repairing Based on Process Model and Activity Description Templates

IEEE Access, 2020
Textual descriptions of business process models are used as guidance for business executives. While it makes process models much easier to understand, missing procedural text is an important practical problem.
Qingtian Zeng, Xiaojie Tang, Weijian Ni, Hua Duan, Chao Li, Nengfu Xie   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

INFORMATION EXTRACTION FROM CHEMICAL PATENTS

Computer Science, 2012
The development of new chemicals or pharmaceuticals is preceded by an indepth analysis of published patents in this field. This information retrieval is a costly and time inefficient step when done by a human reader, yet it is mandatory for potential success of an investment.
Bergmann, S., Romberg, M., Zimmermann, M., Klenner, A.   +3 more
openaire   +4 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Using Large Language Models for Extracting Structured Information From Scientific Texts

Current Directions in Biomedical Engineering
Extracting structured information from scientific works is challenging as sought parameters or properties are often scattered across lengthy texts. We introduce a novel iterative approach using Large Language Models (LLMs) to automate this process.
Rettenberger Luca, Münker Marc F., Schutera Mark, Niemeyer Christof M., Rabe Kersten S., Reischl Markus   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Bootstrapping Knowledge Graphs From Images and Text

Frontiers in Neurorobotics, 2019
The problem of generating structured Knowledge Graphs (KGs) is difficult and open but relevant to a range of tasks related to decision making and information augmentation.
Jiayuan Mao, Yuan Yao, Stefan Heinrich, Tobias Hinz, Cornelius Weber, Stefan Wermter, Zhiyuan Liu, Maosong Sun   +7 more
doaj   +1 more source