Results 81 to 90 of about 3,082,391 (312)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Information extraction from template-generated hidden web documents [PDF]

open access: yes, 2004
The larger amount of information on the Web is stored in document databases and is not indexed by general-purpose search engines (such as Google and Yahoo).
Hedley, Y.   +3 more
core  

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Using Large Language Model to Optimize Protein Purification: Insights from Protein Structure Literature Associated with Protein Data Bank

open access: yesAdvanced Science
Obtaining pure and homogeneous protein samples is vital for protein biology studies, yet optimizing protein expression and purification methods can be time‐consuming because of variations in factors like expression conditions, buffer components, and ...
Zhuojian Chen, J. Sivaraman
doaj   +1 more source

INFORMATION EXTRACTION FROM CHEMICAL PATENTS

open access: yesComputer Science, 2012
The development of new chemicals or pharmaceuticals is preceded by an indepth analysis of published patents in this field. This information retrieval is a costly and time inefficient step when done by a human reader, yet it is mandatory for potential success of an investment.
Bergmann, S.   +3 more
openaire   +4 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Handling uncertainty in information extraction [PDF]

open access: yes, 2011
This position paper proposes an interactive approach for developing information extractors based on the ontology definition process with knowledge about possible (in)correctness of annotations.
Habib, Mena B., Keulen, Maurice van
core   +1 more source

Towards optimal extraction of cosmological information from nonlinear data

open access: yes, 2017
One of the main unsolved problems of cosmology is how to maximize the extraction of information from nonlinear data. If the data are nonlinear the usual approach is to employ a sequence of statistics (N-point statistics, counting statistics of clusters ...
Aslanyan, Grigor   +3 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Web Content Mining for Information on Information Scientists [PDF]

open access: yes, 2011
This paper presents a search system for information on scientists which was implemented prototypically for the area of information science, employing Web Content Mining techniques.
Risse, Sarah
core  

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