Results 101 to 110 of about 24,033,162 (387)

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Automated Data Management Information System (ADMIS) [PDF]

, 1974
ADMIS stores and controls data and documents associated with manned space flight effort. System contains all data oriented toward a specific document; it is primary source of reports generated by the system.
Blackstone, C., Buehler, D., Dunn, D., Feeley, J., Hoffiditz, T., Pratt, L., Rose, J., Smithson, M., Sullivan, E., Whitlock, J.   +9 more
core   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Towards the Uptake of Digital Technologies for Construction Information Management: A Partial Least Squares Structural Equation Modelling Approach

Buildings
The primary objective of this study survey is to close knowledge gaps by measuring the responses from construction experts and investigating the significant effects of using digital technologies in construction information management (CIM).
Peter Adekunle, Clinton Aigbavboa, Opeoluwa Akinradewo, Matthew Ikuabe, Kenneth Otasowie   +4 more
doaj   +1 more source

Personal information management [PDF]

, 1996
We have looked at parallels between ‘old’ technology and ‘old ways’ of managing information and the situation facing us today. We have also suggested that professionals in a changing business environment need a new set of skills to achieve effectiveness.
Barbara Etzel, Peter Thomas
openaire   +2 more sources

Medical Information Management System (MIMS): An automated hospital information system [PDF]

, 1973
Flexible system of computer programs allows manipulation and retrieval of data related to patient care.
Alterescu, S., Collins, L. S., Schwarz, R. A.   +2 more
core   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Delineation of Soil Management Zones and Validation through the Vigour of a Fodder Crop

AgriEngineering
In Mediterranean farming systems, the semi-arid conditions and agricultural ecosystems have made site-specific management an important approach.
Luís Alcino Conceição, Luís Silva, Constantino Valero, Luís Loures, Benvindo Maçãs   +4 more
doaj   +1 more source

How Platforms are Transforming Customer Information Management

, 2017
Purpose The purpose of this paper is to explain how ecosystems and platforms have evolved to manage customer information and to identify the management, research and teaching implications of this evolution. Design/methodology/approach
M. Stone, Eleni Aravopoulou, Gherardo G. G. Girardi, Luisa Weinzierl, Paul Laughlin, Ryan Stott, E. Todeva   +6 more
semanticscholar   +1 more source