Results 61 to 70 of about 27,999,542 (330)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Inkjet-Printed Dielectric Layer for the Enhancement of Electrowetting Display Devices

Nanomaterials
Electrowetting with a dielectric layer is commonly preferred in practical applications. However, its potential is often limited by factors like the properties of the dielectric layer and its breakdown, along with the complexity of the deposition method ...
Hongwei Jiang, Rongzhen Qian, Tinghong Yang, Yuanyuan Guo, Dong Yuan, Biao Tang, Rui Zhou, Hui Li, Guofu Zhou   +8 more
doaj   +1 more source

Dynamic Adjustment and Distinguishing Method for Vehicle Headlight Based on Data Access of a Thermal Camera

Frontiers in Physics, 2020
In recent years, more and more traffic accidents have been caused by the illegal use of high beams. Therefore, the distinguishing of the vehicle headlight is vital for night driving and traffic supervision.
Shixiao Li, Pengfei Bai, Pengfei Bai, Yuanfeng Qin   +3 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Optimizing Bipolar Reset Waveform to Improve Grayscale Stability in Active Matrix Electrowetting Displays

Micromachines
The electrowetting display (EWD) device is a new type of electrowetting-on-dielectric (EWOD) equipment that can achieve a paper-like display effect under the control of an electric field.
Taiyuan Zhang, Li Wang, Linwei Liu, Wei Li, Shipeng Wu, Jianyang Guo, Guofu Zhou   +6 more
doaj   +1 more source

Driving Waveform Design of Electrowetting Displays Based on an Exponential Function for a Stable Grayscale and a Short Driving Time

Micromachines, 2020
The traditional driving waveform of the electrowetting display (EWD) has many disadvantages, such as the large oscillation of the target grayscale aperture ratio and a long time for achieving grayscale.
Zichuan Yi, Zhenyu Huang, Shufa Lai, Wenyao He, Li Wang, Feng Chi, Chongfu Zhang, Lingling Shui, Guofu Zhou   +8 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Replicating CD Nanogrooves onto PDMS to Guide Nanowire Growth for Monolithic Flexible Photodetectors with High Bending‐Stable UV–vis–NIR Photoresponse

Advanced Science
Guided nanowires grown on polymer surfaces facilitate their seamless integration as flexible devices without post‐growth processing steps. However, this is challenging due to the inability of polymer films to provide the required lattice‐matching effect.
Hanyu Liu, Wei Zhou, Xiangtao Chen, Pingyang Huang, Xingyu Wang, Guofu Zhou, Jinyou Xu   +6 more
doaj   +1 more source