Results 91 to 100 of about 18,320,280 (211)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Advances in Multimedia Information Processing - PCM 2002
, 2002 [[abstract]]The following topics are dealt with: multimedia information processing; mobile multimedia; digital watermarking; data hiding; motion analysis; multimedia retrieval; image processing; multimedia security; image coding; multimedia learning ...
Chen, Y-C;Chang, L-W;Hsu, C-T +2 more
core +1 more source
, 2022 Signal Processing (IIH-MSP-2010), it is our pleasure to present to you the conference proceedings. Multimedia technologies with an increasing level of intelligence are emerging to enable the process of creating a global information infrastructure that ...
core +1 more source
An Improved Method for Named Entity Recognition and Its Application to CEMR
Future Internet, 2019 Named Entity Recognition (NER) on Clinical Electronic Medical Records (CEMR) is a fundamental step in extracting disease knowledge by identifying specific entity terms such as diseases, symptoms, etc.
Ming Gao +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
General Information Theory: Some Macroscopic Dynamics of the Human Thinking Systems
, 1997 Information Processing and Management342-3275 ...
Liang, Thow Yick +2 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
IET Radar, Sonar & NavigationIn this paper, a convolutional neural network (CNN) based algorithm for joint estimation of direction of arrival (DOA) and polarisation parameters is introduced.
Pangzhe Li, Dexiu Hu, Chuang Zhao
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source