Results 81 to 90 of about 13,332,800 (308)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

FAIR Aspects of a Health Information Protection and Management System. [PDF]

Methods Inf Med, 2022
Delgado J, Llorente S.
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Information Security Current Problems

Безопасность информационных технологий, 2010
The current problems of information security maintenance and information protection as one of the main factors for successful implementation of Strategy of the Information Society Development in Russia are analyzed.
A. A. Malyuk
doaj  

On certain aspects of standardization and operating conditions of automated systems

Вестник Дагестанского государственного технического университета: Технические науки
Objective. In this paper, the main aspects of the operating conditions of the AS are considered, as well as the issues of standardization of the stages of the life cycle of the AS (creation, commissioning, maintenance, etc.) at the state level.
A. O. Efimov, I. I. Livshits, M. O. Meshcheryakov, E. A. Rogozin, V. R. Romanova   +4 more
doaj   +1 more source

Specific features of the formation of an acoustoelectric channel of speech information leakage

Безопасность информационных технологий, 2017
We address the problem of assessing the protection level of the acoustoelectric channel of speech information with respect to leakages associated with specific operation principles of various electromechanical transducers.
Sergei B. Kozlachkov, Andrew M. Bonch-Bruevich, Sergey V. Dvoryankin, Nadezhda V. Vasilevskaya, Alexandra L. Selenina   +4 more
doaj   +1 more source

Retracted: Analysis of Legal Issues of Personal Information Protection in the Field of Big Data. [PDF]

J Environ Public Health, 2023
Environmental And Public Health JO.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Study on the Definition and Classification of Neural Data in Brain-Computer Interfaces

Yixue yu zhexue
Brain-computer interface (BCI) neural data refers to information that is directly generated, derived, or inferred through the decoding of neural activity. Its mode of generation imparts both identifiability and inferability.
Xin NING
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source