Results 61 to 70 of about 18,353,341 (305)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Protection of Information and Communication Systems [PDF]

, 2013
Awareness, education and protection of organizational information secure environments are currently highly serious and relevant topics. The paper deals with the perspectives and possibilities of "new approaches" to the protection of information and communication systems and nets as a part of Czech Republic critical infrastructure.
Jirí Barta, Veronika Sadovská, Albert Srník, Jiri F. Urbanek   +3 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

MODEL OF THE PROCESS OF FUNCTIONING OF THE INFORMATION PROTECTION SYSTEM FROM UNAUTHORIZED ACCESS CREATED IN THE SOFTWARE ENVIRONMENT OF IMITATION MODELING "CPN TOOLS"

Вестник Дагестанского государственного технического университета: Технические науки, 2019
Objectives. At present, conducting a computational experiment on a system for protecting information from unauthorized access operated in an automated system is a time consuming process.
O. I. Bokova, I. G. Drovnikov, A. D. Popov, E. A. Rogozin   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Organization of the Own System of the Numeration for the Full Search Arguments at the Global Extremum Determination

Безопасность информационных технологий, 2011
The algorithm of the full search of the arguments for the conditional optimization of the multi-dimensional criterion is suggested. Determination consists of the serial numerical optimization several coefficients with the own numeration of the each ...
N. A. Kritsyna, Y. P. Kulyabichev, A. A. Malyuk, A. A. Sukhanov   +3 more
doaj  

METHODS FOR PROTECTING SPEECH INFORMATION [PDF]

Prikladnaya diskretnaya matematika, 2008
Summary: Telephone conversations are the major channel of information interaction. The requirements for maintenance of speech confidentiality and for protecting information having the speech nature are growing. In the paper some problems arising in connection with the speech information protection are considered, and some ways for solving them are ...
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source