Results 51 to 60 of about 4,412,712 (309)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Analysis of the architecture and functions of protected automated systems installed at internal affairs facilities

Вестник Дагестанского государственного технического университета: Технические науки, 2020
Aim. One of the key objectives of the theory and practice of information security is to analyse the functioning of protected automated systems, particularly those operated at computerized facilities of internal affairs bodies.
Yu. M. Barkalov, I. G. Drovnikova, A. M. Kadnova, E. S. Ovchinnikova, E. A. Rogozin   +4 more
doaj   +1 more source

Applying the take-grant protection model [PDF]

, 1990
The Take-Grant Protection Model has in the past been used to model multilevel security hierarchies and simple protection systems. The models are extended to include theft of rights and sharing information, and additional security policies are examined ...
Bishop, Matt
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A simulation model for identifying information security threats from low-frequency acoustoelectric transformations

Вестник Дагестанского государственного технического университета: Технические науки, 2020
Aim. The article considers the physical basis for the formation of a technical channel of information leakage due to low-frequency acoustoelectric transformations. Methods. The research was based on simulation modelling methods.
D. A. Korochentsev, L. V. Cherkesova, K. A. Namavir   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Research of the information security environment of pharmaceutical organizations in the context of the transformation of pharmaceutical practice

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
The article presents the results of a study of the information security environment of the pharmaceutical sector (ISEP) amid the transformation of pharmaceutical practice in Ukraine.
N. O. Tkachenko , S. S. Mysiura
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Realization of universal nonadiabatic geometric control on decoherence-free qubits in the XY model

, 2017
A fundamental requirement of quantum information processing is the protection from the adverse effects of decoherence and noise. Decoherence-free subspaces and geometric processing are important steps of quantum information protection. Here, we provide a
Mousolou, Vahid Azimi
core   +1 more source