Results 131 to 140 of about 1,048,956 (299)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Integrating spatial econometric information and optimisation models to improve Agri-Environmental payment design: A resource allocation model for Emilia-Romagna (Italy)

, 2017
Daniele Vergamini, Davide Viaggi, Meri Raggi, Daniele, Vergamini, Viaggi, Davide, Raggi, Meri   +5 more
openalex   +2 more sources

The Value Of Human Resource Information Systems In Human Resource Management [PDF]

, 2013
Oyoo Mark Okinyi, Kelvin Kabeti Omieno, Kitone K. Margaret   +2 more
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

MODERATING EFFECT OF TOP MANAGEMENT COMMITMENT ON HUMAN RESOURCE INFORMATION SYSTEM AND ORGANIZATIONAL PERFORMANCE IN COMMERCIAL STATE CORPORATIONS IN KENYA

, 2018
Ann Gaceri Kaaria, Mary Kamaara, Joyce Nzulwa, Kepha Ombui   +3 more
openalex   +2 more sources

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Electronic Health-Information Resource Utilization and Its Associated Factors among Health Professionals in Amhara Regional State Teaching Hospitals, Ethiopia. [PDF]

Adv Med Educ Pract, 2021
Tesfa GA, Kalayou MH, Zemene W.
europepmc   +1 more source

Weather, Climate, and Resource Information Should Meet the Needs of Sahelian Pastoralists [PDF]

, 2014
Laura Vang Rasmussen, Ole Mertz, Kjeld Rasmussen, Héctor Nieto, Abdou Ali, I. Maïga   +5 more
openalex   +1 more source